Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

Z Yuan, Y Li, S Zhang, X Wang, H Dou, X Yu, Z Zhang… - Molecular cancer, 2023 - Springer
The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Cisplatin in ovarian cancer treatment—known limitations in therapy force new solutions

A Zoń, I Bednarek - International journal of molecular sciences, 2023 - mdpi.com
Cisplatin is one of the most commonly used anticancer drugs worldwide. It is mainly used in
the treatment of ovarian cancer, but also used in testicular, bladder and lung cancers. The …

Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets

Q Zhang, DK Jeppesen, JN Higginbotham… - Nature cell …, 2021 - nature.com
Extracellular vesicles and exomere nanoparticles are under intense investigation as sources
of clinically relevant cargo. Here we report the discovery of a distinct extracellular …

[HTML][HTML] TGFBI secreted by tumor-associated macrophages promotes glioblastoma stem cell-driven tumor growth via integrin αvβ5-Src-Stat3 signaling

P Peng, H Zhu, D Liu, Z Chen, X Zhang, Z Guo… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: In the glioblastoma (GBM) microenvironment, tumor-associated macrophages
(TAMs) are prominent components and facilitate tumor growth. The exact molecular …

[HTML][HTML] Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment

E Schoutrop, L Moyano-Galceran, S Lheureux… - Seminars in cancer …, 2022 - Elsevier
Ovarian cancer encompasses a heterogeneous group of malignancies that involve the
ovaries, fallopian tubes and the peritoneal cavity. Despite major advances made within the …

[HTML][HTML] Targeting tumor-associated macrophages for successful immunotherapy of ovarian carcinoma

I Truxova, D Cibula, R Spisek… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Epithelial ovarian cancer (EOC) is among the top five causes of cancer-related death in
women, largely reflecting early, prediagnosis dissemination of malignant cells to the …

Tumor-associated macrophages and ovarian cancer: implications for therapy

D Schweer, A McAtee, K Neupane, C Richards… - Cancers, 2022 - mdpi.com
Simple Summary Ovarian cancer is a highly lethal female malignancy with high rates of
advanced stage and recurrent disease. Ovarian cancer is characterized as poorly …

[HTML][HTML] TGF-β, EMT, and resistance to anti-cancer treatment

X Wang, PJA Eichhorn, JP Thiery - Seminars in Cancer Biology, 2023 - Elsevier
Transforming growth factor-β (TGF-β) signaling regulates cell-specific programs involved in
embryonic development, wound-healing, and immune homeostasis. Yet, during tumor …

[HTML][HTML] Extracellular matrix in high-grade serous ovarian cancer: Advances in understanding of carcinogenesis and cancer biology

Y Brown, S Hua, PS Tanwar - Matrix Biology, 2023 - Elsevier
High-grade serous ovarian cancer (HGSOC) is notoriously known as the “silent killer” of post-
menopausal women as it has an insidious progression and is the deadliest gynaecological …

The transcoelomic ecosystem and epithelial ovarian cancer dissemination

SJ Ritch, CM Telleria - Frontiers in Endocrinology, 2022 - frontiersin.org
Epithelial ovarian cancer (EOC) is considered the deadliest gynecological disease and is
normally diagnosed at late stages, at which point metastasis has already occurred …