Systemic inflammation can be triggered by infection, surgery, trauma or burns. During
systemic inflammation, an overshooting immune response induces tissue damage resulting …

During nervous system development, neurons extend axons to reach their targets and form
functional circuits. The faulty assembly or disintegration of such circuits results in disorders …

The anterolateral pathway consists of ascending spinal tracts that convey pain, temperature
and touch information from the spinal cord to the brain,,–. Projection neurons of the …

Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed
exome sequencing and copy number analysis to define genomic aberrations in a …

Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is
best known for mediating axon repulsion in the developing nervous system. However, in …

The corticospinal tract (CST) plays a major role in cortical control of spinal cord activity. In
particular, it is the principal motor pathway for voluntary movements. Here, we discuss:(i) the …

The complex patterns of neuronal wiring in the adult nervous system depend on a series of
guidance events during neural development that establish a framework on which functional …

Naturally occurring axonal pruning and neuronal cell death help to sculpt neuronal
connections during development, but their mechanistic basis remains poorly understood …

Blood vessels and nerve fibres course throughout the body in an orderly pattern, often
alongside one another. Although superficially distinct, the mechanisms involved in wiring …

Abstract N 6-Methyladenosine (m6A) is a dynamic mRNA modification which regulates
protein expression in various posttranscriptional levels. Functional studies of m6A in …