Fast, high-resolution, non-destructive and quantitative characterization methods are needed
to develop materials with tailored properties at the nanoscale or to understand the …

Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …

The mechanical properties of cells influence their cellular and subcellular functions,
including cell adhesion, migration, polarization, and differentiation, as well as organelle …

The tumor microenvironment is a dynamic landscape in which the physical and mechanical
properties evolve dramatically throughout cancer progression. These changes are driven by …

Growing interest in exploring mechanically mediated biological phenomena has resulted in
cell culture substrates and 3D matrices with variable stiffnesses becoming standard tools in …

Morphogenesis, tumor formation, and wound healing are regulated by tissue rigidity. Focal
adhesion behavior is locally regulated by stiffness; however, how cells globally adapt …

Cancer development and progression are closely associated with changes both in the
mechano-cellular phenotype of cancer and stromal cells and in the extracellular matrix …

Metastasis is a dynamic process in which cancer cells navigate the tumor microenvironment,
largely guided by external chemical and mechanical cues. Our current understanding of …

Cortical stiffness is an important cellular property that changes during migration, adhesion
and growth. Previous atomic force microscopy (AFM) indentation measurements of cells …