Immune modulation after traumatic brain injury

M Bouras, K Asehnoune, A Roquilly - Frontiers in Medicine, 2022 - frontiersin.org
Traumatic brain injury (TBI) induces instant activation of innate immunity in brain tissue,
followed by a systematization of the inflammatory response. The subsequent response …

A proteomic analysis of NETosis in trauma: Emergence of serpinB1 as a key player

TR Schaid Jr, I LaCroix, KC Hansen… - Journal of Trauma …, 2023 - journals.lww.com
BACKGROUND Release of neutrophil extracellular traps (NETosis) may mediate postinjury
organ dysfunction, but mechanisms remain unclear. The intracellular serine protease …

Neutrophil heterogeneity and emergence of a distinct population of CD11b/CD18-activated low-density neutrophils after trauma

IG Riça, BA Joughin, ME Teke… - Journal of Trauma …, 2023 - journals.lww.com
METHODS A total of 74 samples from 12 trauma patients, each sampled at 1 or more time
points, and matched controls were fractionated and profiled by mass-spectrometry–based …

Leishmania infantum infection modulates messenger RNA, microRNA and long non-coding RNA expression in human neutrophils in vitro

NF Scaramele, JA Troiano, JS Felix… - PLOS Neglected …, 2024 - journals.plos.org
In the Americas, L. infantum (syn. chagasi) is the main cause of human visceral
leishmaniasis. The role of neutrophils as part of the innate response to Leishmania spp …

The Posttraumatic Increase of the Adhesion GPCR EMR2/ADGRE2 on Circulating Neutrophils Is Not Related to Injury Severity

L Zheng, M Rang, C Fuchs, A Keß, M Wunsch… - Cells, 2023 - mdpi.com
Trauma triggers a rapid innate immune response to aid the clearance of damaged/necrotic
cells and their released damage-associated molecular pattern (DAMP). Here, we monitored …

[HTML][HTML] A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation

E Karasu, R Halbgebauer, L Schütte, J Greven… - BMC …, 2025 - pmc.ncbi.nlm.nih.gov
Background C-reactive protein (CRP) represents a routine diagnostic marker of
inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure …

[HTML][HTML] Association Between Neutrophil Density and Survival in Trauma Patients Admitted to the Intensive Care Unit; a Retrospective Cohort Study

M Vali, S Paydar, M Seif, M Hosseini… - Archives of Academic …, 2023 - ncbi.nlm.nih.gov
Methods: The current retrospective cohort study was conducted using data from patients
admitted in the intensive care unit (ICU) of a trauma center in Shiraz, Iran, between 2016 …

The Network of miRNA–mRNA Interactions in Circulating T Cells of Patients Following Major Trauma–A Pilot Study

CS Rau, PJ Kuo, HP Lin, CJ Wu, YC Wu… - Journal of …, 2022 - Taylor & Francis
Purpose Following major trauma, genes involved in adaptive immunity are downregulated,
which accompanies the upregulation of genes involved in systemic inflammatory responses …

Effect of severity of injury on immune system and its role in patient outcome in patients with Blunt Trauma to the chest

P Kabiraj, P Mathur, N Rajput, P Priyadarshini… - 2024 - researchsquare.com
BACKGROUND Chest injuries are one of the most common injuries which are admitted in
the trauma and emergency departments. It is known that the immune system affects the …

Healing after Trauma—New Knowledge and Procedures for the Benefit of Our Patients

C Neunaber, M Fini, P Cinelli - Life, 2022 - mdpi.com
Severe trauma is still the leading cause of death and disability in the world [1]. These
severely injured patients have a particularly high risk of developing complications, which …