How do lncRNAs regulate transcription?
It has recently become apparent that RNA, itself the product of transcription, is a major
regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs) …
regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs) …
Histone deacetylases (HDACs): evolution, specificity, role in transcriptional complexes, and pharmacological actionability
G Milazzo, D Mercatelli, G Di Muzio, L Triboli… - Genes, 2020 - mdpi.com
Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …
removing acetyl groups from histones and other protein regulatory factors, with functional …
PRC2 is high maintenance
As the process that silences gene expression ensues during development, the stage is set
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene …
Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes
The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …
de-regulation of this timing promotes the formation of cancer and leads to defects during …
Targeting class I histone deacetylases in a “complex” environment
CJ Millard, PJ Watson, L Fairall… - Trends in pharmacological …, 2017 - cell.com
Histone deacetylase (HDAC) inhibitors are proven anticancer therapeutics and have
potential in the treatment of many other diseases including HIV infection, Alzheimer's …
potential in the treatment of many other diseases including HIV infection, Alzheimer's …
Roles of histone deacetylases and inhibitors in anticancer therapy
Histones are the main structural proteins of eukaryotic chromatin. Histone acetylation/
deacetylation are the epigenetic mechanisms of the regulation of gene expression and are …
deacetylation are the epigenetic mechanisms of the regulation of gene expression and are …
Unique structural platforms of Suz12 dictate distinct classes of PRC2 for chromatin binding
Developmentally regulated accessory subunits dictate PRC2 function. Here, we report the
crystal structures of a 120 kDa heterotetrameric complex consisting of Suz12, Rbbp4, Jarid2 …
crystal structures of a 120 kDa heterotetrameric complex consisting of Suz12, Rbbp4, Jarid2 …
Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis
Developmental silencing of fetal globins serves as both a paradigm of spatiotemporal gene
regulation and an opportunity for therapeutic intervention of β-hemoglobinopathy. The …
regulation and an opportunity for therapeutic intervention of β-hemoglobinopathy. The …
Structures of monomeric and dimeric PRC2: EZH1 reveal flexible modules involved in chromatin compaction
Abstract Polycomb repressive complex 2 (PRC2) is a histone methyltransferase critical for
maintaining gene silencing during eukaryotic development. In mammals, PRC2 activity is …
maintaining gene silencing during eukaryotic development. In mammals, PRC2 activity is …
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD
To understand how the nucleosome remodeling and deacetylase (NuRD) complex
regulates enhancers and enhancer–promoter interactions, we have developed an approach …
regulates enhancers and enhancer–promoter interactions, we have developed an approach …