Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …

We are researchers and clinicians working on Alzheimer's disease (AD) or related topics,
and we write to express our concern that one particular aspect of the disease has been …

Strong evidence has emerged recently for the concept that herpes simplex virus type 1
(HSV1) is a major risk for Alzheimer's disease (AD). This concept proposes that latent HSV1 …

The amyloid-β (Aβ) peptide has long been considered to be the driving force behind
Alzheimer's disease (AD). However, clinical trials that have successfully reduced Aβ burden …

The amyloid cascade hypothesis, focusing on pathological proteins aggregation, has so far
failed to uncover the root cause of Alzheimer's disease (AD), or to provide an effective …

Herpes simplex virus type 1 (HSV1), when present in brain of carriers of the type 4 allele of
the apolipoprotein E gene (APOE), has been implicated as a major factor in Alzheimer's …

A growing body of epidemiologic and experimental data point to chronic bacterial and viral
infections as possible risk factors for neurodegenerative diseases, including Alzheimer's …

This review focuses on research in the areas of epidemiology, neuropathology, molecular
biology and genetics that implicates herpes simplex virus type 1 (HSV-1) as a causative …

The proposed molecular mechanisms underlying neurodegenerative pathogenesis are
varied, precluding the development of effective therapies for these increasingly prevalent …

Support for the concept that herpes simplex virus type 1 (HSV1), when present in the brains
of apolipoprotein E‐«4 carriers, is a major risk for Alzheimer's disease (AD) is increasing …