The initiation and maintenance of reproductive capacity in humans is dependent on pulsatile
secretion of the hypothalamic hormone GnRH. Congenital hypogonadotropic hypogonadism …

It is predicted that Japan and European Union will soon experience appreciable decreases
in their populations due to persistently low total fertility rates (TFR) below replacement level …

Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by the
deficient production, secretion or action of gonadotropin-releasing hormone (GnRH), which …

Sex differences in longevity can provide insights into novel mechanisms of aging, yet they
have been little studied. Surprisingly, sex-specific longevity patterns are best known in wild …

The hypothalamic-pituitary-gonadal (HPG) axis is active in the midgestational foetus but
silenced towards term because of the negative feedback effects mediated by the placental …

Postnatal development includes dramatic changes in gonadal hormones and the many
social behaviors they help regulate, both in rodents and humans. Parental care-seeking is …

Background Anti-Müllerian hormone (AMH) is a product of growing ovarian follicles. The
concentration of AMH in blood may also reflect the non-growing follicle (NGF) population, ie …

Minipuberty consists of activation of the hypothalamic-pituitary-gonadal (HPG) axis during
the neonatal period, resulting in high gonadotropin and sex steroid levels, and occurs …

Phthalates adversely affect the male reproductive system in animals. We investigated
whether phthalate monoester contamination of human breast milk had any influence on the …

An increase in pulsatile release of LHRH is essential for the onset of puberty. However, the
mechanism controlling the pubertal increase in LHRH release is still unclear. In primates the …