Methodological developments for metabolic NMR spectroscopy from cultured cells to tissue extracts: Achievements, progress and pitfalls
NW Lutz, M Bernard - Molecules, 2022 - mdpi.com
This is a broad overview and critical review of a particular group of closely related ex vivo
and in vitro metabolic NMR spectroscopic methods. The scope of interest comprises studies …
and in vitro metabolic NMR spectroscopic methods. The scope of interest comprises studies …
StereoPHIP: Stereoselective Parahydrogen‐Induced Polarization
MT Huynh, E Buchanan, S Chirayil… - Angewandte Chemie …, 2023 - Wiley Online Library
Parahydrogen‐induced polarization (PHIP) followed by polarization transfer to 13C is a
rapidly developing technique for the generation of 13C‐hyperpolarized substrates. Chirality …
rapidly developing technique for the generation of 13C‐hyperpolarized substrates. Chirality …
Design, Synthesis, and Assessment of Tricarboxylic Acid Cycle Probes
J Chen, D Chao, UP Tran, KL Billingsley - Synthesis, 2024 - thieme-connect.com
Hyperpolarized 13 C magnetic resonance spectroscopy can provide unique insights into
metabolic activity in vivo. Despite the advantages of this technology, certain metabolic …
metabolic activity in vivo. Despite the advantages of this technology, certain metabolic …
Technical considerations of MRI methods for validating DNP probes in small animals
Probes that are developed for dissolution dynamic nuclear polarization (DNP) should meet
numerous requirements such as solubility, glassing, and spin-lattice relation time, yet only a …
numerous requirements such as solubility, glassing, and spin-lattice relation time, yet only a …
Beyond 13C-pyruvate: Prospects for biomedical applications of alternative hyperpolarized probes and isotopes
M Mishkovsky, HAI Yoshihara - Advances in Magnetic Resonance …, 2024 - Elsevier
The past 2 decades have witnessed an extensive development of nuclear spin
hyperpolarization technologies. The capability to produce solutions of hyperpolarized …
hyperpolarization technologies. The capability to produce solutions of hyperpolarized …
Hyperpolarized tracer design, synthesis, and characterization
While NMR offers valuable chemical information, its sensitivity is inherently limited. The
utilization of hyperpolarized NMR techniques, however, can produce significantly enhanced …
utilization of hyperpolarized NMR techniques, however, can produce significantly enhanced …