Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

The transcription factor NRF2 (nuclear factor erythroid 2‐related factor 2) triggers the first
line of homeostatic responses against a plethora of environmental or endogenous …

Oxidative stress is a pathological condition occurring due to an imbalance between the
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …

Despite the capacity of chaperones and other homeostatic components to restore folding
equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer …

Nuclear factor erythroid 2–related factor 2 (Nrf2) is a transcription factor that promotes the
transcription of cytoprotective genes in response to oxidative and electrophilic stresses. Most …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that positively
regulates the basal and inducible expression of a large battery of cytoprotective genes …

Liver diseases represent a critical health problem with 2 million deaths worldwide per year,
mainly due to cirrhosis and its complications. Oxidative stress plays an important role in the …

Sandwich-cultured hepatocytes (SCH) are a powerful in vitro tool that can be utilized to
study hepatobiliary drug transport, species differences in drug transport, transport protein …

Chronic cholestasis and liver inflammation are the two main pathophysiological components
of the two major classes of disease–primary biliary cirrhosis (PBC) and primary sclerosing …

The NLRP3 inflammasome is an intracellular multiprotein complex that plays an essential
role in the innate immune system by identifying and eliminating a plethora of endogenous …