Abstract Moorman, Antoon FM, and Vincent M. Christoffels. Cardiac Chamber Formation:
Development, Genes, and Evolution. Physiol Rev 83: 1223-1267, 2003; 10.1152/physrev …

Congenital diaphragmatic hernias (CDHs) and structural anomalies of the diaphragm are a
common class of congenital birth defects that are associated with significant morbidity and …

INTRODUCTION The vertebrate heart is composed of diverse cell types, all essential for
normal cardiac function. In the mouse, the earliest mesodermal progenitors of …

Each cell lineage specified in the preimplantation mammalian embryo depends on intrinsic
factors for its development, but there is also mutual interdependence between them. OCT4 is …

Cardiac development arises from two sources of mesoderm progenitors, the first heart field
(FHF) and the second (SHF). Mesp1 has been proposed to mark the most primitive …

Mesodermal signaling is critical for patterning the embryonic endoderm into different tissue
domains. Classical tissue transplant experiments in the chick and recent studies in the …

Studying the formation of the embryonic axes in mammals poses a special problem because
patterning of the embryo itself is a relatively late event in development. In the mouse, explicit …

To further define the role of a T-box transcription factor, Tbx5, in cardiac development, we
have examined its expression in the developing mouse and chick heart and correlated this …

The extra-embryonic endoderm lineage plays a major role in the nutritive support of the
embryo and is required for several inductive events, such as anterior patterning and blood …

The homeobox gene Hex is expressed in the anterior visceral endoderm (AVE) and rostral
definitive endoderm of early mouse embryos. Later, Hex transcripts are detected in liver …