Mesothelin secretion by pancreatic cancer cells co-opts macrophages and promotes metastasis
T Luckett, M Abudula, L Ireland, M Glenn, G Bellomo… - Cancer Research, 2024 - AACR
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease, yet effective
treatments to inhibit PDAC metastasis are lacking. The rich PDAC tumor microenvironment …
treatments to inhibit PDAC metastasis are lacking. The rich PDAC tumor microenvironment …
Potential Therapeutic Targets in Myeloid Cell Therapy for Overcoming Chemoresistance and Immune Suppression in Gastrointestinal Tumors
J Fan, J Zhu, H Zhu, H Xu - Critical Reviews in Oncology/Hematology, 2024 - Elsevier
In the tumor microenvironment (TME), myeloid cells play a pivotal role. Myeloid-derived
immunosuppressive cells, including tumor-associated macrophages (TAMs) and myeloid …
immunosuppressive cells, including tumor-associated macrophages (TAMs) and myeloid …
[HTML][HTML] New avenues for the treatment of immunotherapy-resistant pancreatic cancer
LG de Oliveira Silva, FFB Lemos, MS Luz… - World Journal of …, 2024 - ncbi.nlm.nih.gov
Pancreatic cancer (PC) is characterized by its extremely aggressive nature and ranks 14th in
the number of new cancer cases worldwide. However, due to its complexity, it ranks 7th in …
the number of new cancer cases worldwide. However, due to its complexity, it ranks 7th in …
[HTML][HTML] Immunoglobulin superfamily 6 is a molecule involved in the anti-tumor activity of macrophages in lung adenocarcinoma
Q Zheng, T Wang, G Jiang, M Li, Z Zhang, Y Chen… - BMC cancer, 2023 - Springer
Abstract Background Immunoglobulin superfamily 6 (IGSF6) is a novel member of the
immunoglobulin superfamily and has been implicated in various diseases. However, the …
immunoglobulin superfamily and has been implicated in various diseases. However, the …
[HTML][HTML] Necroptosis stimulates interferon-mediated protective anti-tumor immunity
AJ Rucker, CS Park, QJ Li, EA Moseman… - Cell Death & …, 2024 - nature.com
Necroptosis is an inflammatory form of cell suicide that critically depends on the kinase
activity of Receptor Interacting Protein Kinase 3 (RIPK3). Previous studies showed that …
activity of Receptor Interacting Protein Kinase 3 (RIPK3). Previous studies showed that …
Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGFβ
Glucocorticoid synthesis by adrenal glands (AG) is regulated by the hypothalamicpituitary-
adrenal axis (HPA-axis) to facilitate stress responses when the host is exposed to stimuli …
adrenal axis (HPA-axis) to facilitate stress responses when the host is exposed to stimuli …
Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different …
S Sivakumar, A Jainarayanan, E Arbe-Barnes… - bioRxiv, 2023 - biorxiv.org
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis.
Understanding the multiple mechanisms by which the tumour evades immune control, and …
Understanding the multiple mechanisms by which the tumour evades immune control, and …
[HTML][HTML] Tumor-associated macrophages (TAMs): Constructing an immunosuppressive microenvironment bridge for pancreatic ductal adenocarcinoma (PDAC)
R Liu, J Li, L Liu, W Wang, J Jia - Cancer Pathogenesis and Therapy, 2024 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with increasing incidences
worldwide. The overall 5-year survival rate remains low, underscoring the urgent need for …
worldwide. The overall 5-year survival rate remains low, underscoring the urgent need for …
[HTML][HTML] Necroptosis Stimulates Interferon-Mediated Protective Anti-Tumor Immunity
Necroptosis is an inflammatory form of cell suicide that critically depends on the kinase
activity of Receptor Interacting Protein Kinase 3 (RIPK3). Previous studies showed that …
activity of Receptor Interacting Protein Kinase 3 (RIPK3). Previous studies showed that …