Signaling mechanisms and pharmacological modulators governing diverse aquaporin functions in human health and disease

K Wagner, L Unger, MM Salman, P Kitchen… - International Journal of …, 2022 - mdpi.com
The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the
bidirectional transport of water across biological membranes in response to osmotic …

[HTML][HTML] Aquaporins in insulin resistance and diabetes: more than channels!

M Galli, A Hameed, A Żbikowski, P Zabielski - Redox biology, 2021 - Elsevier
Aquaporins (AQPs) are part of the family of the integral membrane proteins. Their function is
dedicated to the transport of water, glycerol, ammonia, urea, H 2 O 2, and other small …

Biodegradable Ferric Phosphate Nanocarriers with Tumor‐Specific Activation and Glutathione Depletion for Tumor Self‐Enhanced Ferroptosis and Chemotherapy

Y Li, W Fan, X Gu, S Liu, T He, S Gou… - Advanced Functional …, 2024 - Wiley Online Library
Ferroptosis is a regulatory cell death that is dependent on iron‐mediated lipid peroxidation
and cell membrane damage. The use of iron‐based nanocarriers to activate ferroptosis is of …

[HTML][HTML] Oxygen-consumption based quantification of chemogenetic H2O2 production in live human cells

WTF den Toom, DMK van Soest, PE Polderman… - Free Radical Biology …, 2023 - Elsevier
Abstract Reactive Oxygen Species (ROS) in the form of H 2 O 2 can act both as
physiological signaling molecules as well as damaging agents, depending on their …

Aquaporin-7 facilitates proliferation and adipogenic differentiation of mouse bone marrow mesenchymal stem cells by regulating hydrogen peroxide transport

Y Ma, J Zhang, Y Li, H Hu, Q Ye, C Yang… - Stem Cell Reviews and …, 2023 - Springer
Abstract Hydrogen peroxide (H2O2) is a major form of reactive oxygen species that play an
important role in the survival, proliferation and differentiation of bone marrow mesenchymal …

[HTML][HTML] Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer

IV da Silva, M Mlinarić, AR Lourenço… - International journal of …, 2024 - mdpi.com
Peroxiporins are a specialized subset of aquaporins, which are integral membrane proteins
primarily known for facilitating water transport across cell membranes. In addition to the …

Protective roles of peroxiporins AQP0 and AQP11 in human astrocyte and neuronal cell lines in response to oxidative and inflammatory stressors

Z Amro, LE Collins-Praino, AJ Yool - Bioscience Reports, 2024 - portlandpress.com
In addition to aquaporin (AQP) classes AQP1, AQP4 and AQP9 known to be expressed in
mammalian brain, our recent transcriptomic analyses identified AQP0 and AQP11 in human …

The importance of aquaporin-8 for cytokine-mediated toxicity in rat insulin-producing cells

C Krueger, A Joerns, J Kaynert… - Free Radical Biology …, 2021 - Elsevier
Abstract Aquaporin-8 (AQP8) is a peroxiporin, a transmembrane water and hydrogen
peroxide (H 2 O 2) transport protein expressed in the mitochondrial and plasma membranes …

Dissecting in vivo and in vitro redox responses using chemogenetics

M Waldeck-Weiermair, S Yadav, F Spyropoulos… - Free Radical Biology …, 2021 - Elsevier
Abstract Hydrogen peroxide (H 2 O 2) is the most abundant reactive oxygen species (ROS)
within mammalian cells. At low concentrations, H 2 O 2 serves as a versatile cell signaling …

AQP8 promotes glioma proliferation and growth, possibly through the ROS/PTEN/AKT signaling pathway

Z Hao, S Huajun, G Zhen, X Yu, L Qian, C Ziling… - Bmc Cancer, 2023 - Springer
Background The aquaporin (AQP) family of proteins has been implicated in the proliferation
and growth of gliomas. Expression of AQP8 is higher in human glioma tissues than in …