Lipid droplets and lipid mediators in viral infection and immunity
Lipid droplets (LDs) contribute to key pathways important for the physiology and
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …
Pathogenesis and virulence of flavivirus infections
The Flavivirus genus consists of> 70 members including several that are considered
significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be …
significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be …
SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus
E Branche, YT Wang, KM Viramontes… - Nature …, 2022 - nature.com
The emergence of Zika virus (ZIKV) as a global health threat has highlighted the unmet need
for ZIKV-specific vaccines and antiviral treatments. ZIKV infects dendritic cells (DC), which …
for ZIKV-specific vaccines and antiviral treatments. ZIKV infects dendritic cells (DC), which …
Nucleoside-Modified mRNA Vaccines Protect IFNAR–/– Mice against Crimean-Congo Hemorrhagic Fever Virus Infection
Crimean-Congo hemorrhagic fever (CCHF), caused by Crimean-Congo hemorrhagic fever
virus (CCHFV), is on the World Health Organizations' list of prioritized diseases and …
virus (CCHFV), is on the World Health Organizations' list of prioritized diseases and …
Hijacking of lipid droplets by hepatitis C, dengue and zika viruses—from viral protein moonlighting to extracellular release
APM Cloherty, AD Olmstead, CMS Ribeiro… - International journal of …, 2020 - mdpi.com
Hijacking and manipulation of host cell biosynthetic pathways by human enveloped viruses
are essential for the viral lifecycle. Flaviviridae members, including hepatitis C, dengue and …
are essential for the viral lifecycle. Flaviviridae members, including hepatitis C, dengue and …
Biogenesis and breakdown of lipid droplets in pathological conditions
CM Fader Kaiser, PS Romano, MC Vanrell… - Frontiers in Cell and …, 2022 - frontiersin.org
Lipid droplets (LD) have long been considered as mere fat drops; however, LD have lately
been revealed to be ubiquitous, dynamic and to be present in diverse organelles in which …
been revealed to be ubiquitous, dynamic and to be present in diverse organelles in which …
The antiviral effect of metformin on zika and dengue virus infection
CN Farfan-Morales, CD Cordero-Rivera… - Scientific Reports, 2021 - nature.com
The Dengue (DENV) and zika (ZIKV) virus infections are currently a public health concern.
At present, there is no treatment or a safe and effective vaccine for these viruses. Hence, the …
At present, there is no treatment or a safe and effective vaccine for these viruses. Hence, the …
Lipid droplets and the host–pathogen dynamic: FATal attraction?
In the ongoing conflict between eukaryotic cells and pathogens, lipid droplets (LDs) emerge
as a choke point in the battle for nutrients. While many pathogens seek the lipids stored in …
as a choke point in the battle for nutrients. While many pathogens seek the lipids stored in …
Congenital Zika syndrome: genetic avenues for diagnosis and therapy, possible management and long-term outcomes
G Gullo, M Scaglione, G Cucinella, A Riva… - Journal of Clinical …, 2022 - mdpi.com
Zika virus (ZIKV) was discovered in Uganda in 1947 and was originally isolated only in
Africa and Asia. After a spike of microcephaly cases in Brazil, research has closely focused …
Africa and Asia. After a spike of microcephaly cases in Brazil, research has closely focused …
Redox regulation and metabolic dependency of Zika virus replication: Inhibition by Nrf2-antioxidant response and NAD (H) antimetabolites
Viral infections alter host cell metabolism and homeostasis; however, the mechanisms that
regulate these processes have only begun to be elucidated. We report here that Zika virus …
regulate these processes have only begun to be elucidated. We report here that Zika virus …