Circulating tumor cells: biology and clinical significance
D Lin, L Shen, M Luo, K Zhang, J Li, Q Yang… - Signal transduction and …, 2021 - nature.com
Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and
extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs …
extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs …
Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases
MK Skytthe, JH Graversen, SK Moestrup - International journal of …, 2020 - mdpi.com
The macrophage is a key cell in the pro-and anti-inflammatory response including that of the
inflammatory microenvironment of malignant tumors. Much current drug development in …
inflammatory microenvironment of malignant tumors. Much current drug development in …
Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival
CE Gast, AD Silk, L Zarour, L Riegler, JG Burkhart… - Science …, 2018 - science.org
High lethality rates associated with metastatic cancer highlight an urgent medical need for
improved understanding of biologic mechanisms driving metastatic spread and identification …
improved understanding of biologic mechanisms driving metastatic spread and identification …
Classical epithelial-mesenchymal transition (EMT) and alternative cell death process-driven blebbishield metastatic-witch (BMW) pathways to cancer metastasis
Metastasis is a pivotal event that accelerates the prognosis of cancer patients towards
mortality. Therapies that aim to induce cell death in metastatic cells require a more detailed …
mortality. Therapies that aim to induce cell death in metastatic cells require a more detailed …
Circulating cells with macrophage-like characteristics in cancer: the importance of circulating neoplastic-immune hybrid cells in cancer
Simple Summary In cancer, disseminated neoplastic cells circulating in blood are a source
of tumor DNA, RNA, and protein, which can be harnessed to diagnose, monitor, and better …
of tumor DNA, RNA, and protein, which can be harnessed to diagnose, monitor, and better …
The potential role of leptin in tumor invasion and metastasis
A Ray, MP Cleary - Cytokine & growth factor reviews, 2017 - Elsevier
The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in
obesity compared to its functions in the normal healthy state. In obese individuals, elevated …
obesity compared to its functions in the normal healthy state. In obese individuals, elevated …
E-cadherin in pancreatic ductal adenocarcinoma: A multifaceted actor during EMT
M Sommariva, N Gagliano - Cells, 2020 - mdpi.com
Epithelial-to-mesenchymal transition (EMT) is a step-wise process observed in normal and
tumor cells leading to a switch from epithelial to mesenchymal phenotype. In tumors, EMT …
tumor cells leading to a switch from epithelial to mesenchymal phenotype. In tumors, EMT …
Tumor-cell–macrophage fusion cells as liquid biomarkers and tumor enhancers in cancer
Y Manjunath, D Porciani, JB Mitchem… - International journal of …, 2020 - mdpi.com
Although molecular mechanisms driving tumor progression have been extensively studied,
the biological nature of the various populations of circulating tumor cells (CTCs) within the …
the biological nature of the various populations of circulating tumor cells (CTCs) within the …
Cell-cell fusion mediated by viruses and HERV-derived fusogens in cancer initiation and progression
T Dittmar, J Weiler, T Luo, R Hass - Cancers, 2021 - mdpi.com
Simple Summary Even though it is known that (cancer) cells can fuse, it is still less
understood how (cancer) cells merge their plasma membranes, thereby giving rise to bi-and …
understood how (cancer) cells merge their plasma membranes, thereby giving rise to bi-and …
[HTML][HTML] Roles of cell fusion, hybridization and polyploid cell formation in cancer metastasis
I Shabo, J Svanvik, A Lindström… - World journal of …, 2020 - ncbi.nlm.nih.gov
Cell-cell fusion is a normal biological process playing essential roles in organ formation and
tissue differentiation, repair and regeneration. Through cell fusion somatic cells undergo …
tissue differentiation, repair and regeneration. Through cell fusion somatic cells undergo …