The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins—roles in reproduction, cancer, and immune defense

GM Gibbs, K Roelants, MK O'bryan - Endocrine reviews, 2008 - academic.oup.com
The cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP)
superfamily members are found in a remarkable range of organisms spanning each of the …

Molecules involved in mammalian sperm-egg interaction

SB McLeskey, C Dowds, R Carballada… - International Review of …, 1997 - Elsevier
To achieve fertilization, sperm and egg are equipped with specific molecules which mediate
the steps of gamete interaction. In mammals, the first interaction between sperm and egg …

The human cysteine‐rich secretory protein (CRISP) family: primary structure and tissue distribution of CRISP‐1, CRISP‐2 and CRISP‐3

J Krätzschmar, B Haendler… - European journal of …, 1996 - Wiley Online Library
We report the isolation and characterisation of cDNAs encoding three different, human
members of the cysteine‐rich secretory protein (CRISP) family. The novel CRISP‐I exists in …

Primary structure and properties of helothermine, a peptide toxin that blocks ryanodine receptors

J Morrissette, J Krätzschmar, B Haendler, R El-Hayek… - Biophysical journal, 1995 - cell.com
Helothermine, a protein from the venom of the Mexican beaded lizard (Heloderma horridum
horridum), was found to inhibit [3H] ryanodine binding to cardiac and skeletal sarcoplasmic …

Pseudechetoxin: a peptide blocker of cyclic nucleotide-gated ion channels

RL Brown, TL Haley, KA West… - Proceedings of the …, 1999 - National Acad Sciences
Ion channels activated by the binding of cyclic nucleotides first were discovered in retinal
rods where they generate the cell's response to light. In other systems, however, it has been …

The Expression of Cysteine-Rich Secretory Protein 2 (CRISP2) and Its Specific Regulator miR-27b in the Spermatozoa of Patients with Asthenozoospermia

JH Zhou, QZ Zhou, XM Lyu, T Zhu, ZJ Chen… - Biology of …, 2015 - academic.oup.com
Cysteine-rich secretory protein 2 (CRISP2) is an important sperm protein and plays roles in
spermatogenesis, modulation of flagellar motility, acrosome reaction, and gamete fusion …

Evidence for the involvement of testicular protein CRISP2 in mouse sperm-egg fusion

D Busso, NM Goldweic, M Hayashi… - Biology of …, 2007 - academic.oup.com
CRISP2, originally known as Tpx-1, is a cysteine-rich secretory protein specifically
expressed in male haploid germ cells. Although likely to be involved in gamete interaction …

Induced lipid peroxidation in ram sperm: semen profile, DNA fragmentation and antioxidant status

TR dos Santos Hamilton, LS de Castro… - …, 2016 - rep.bioscientifica.com
We hypothesised that antenatal exposure to ubiquitous phthalates may lead to an earlier
menarche and a lower prevalence of polycystic ovarian syndrome (PCOS) and polycystic …

Mouse cysteine-rich secretory protein 4 (CRISP4): a member of the Crisp family exclusively expressed in the epididymis in an androgen-dependent manner

J Jalkanen, I Huhtaniemi, M Poutanen - Biology of Reproduction, 2005 - academic.oup.com
The final maturation of spermatozoa produced in the testis takes place during their passage
through the epididymis. In this process, the proteins secreted into the epididymal lumen …

Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: implications for fertility disorders

NG Brukman, H Miyata, P Torres… - Molecular human …, 2016 - academic.oup.com
STUDY HYPOTHESIS We hypothesize that fertility disorders in patients with aberrant
expression of Cysteine-RIch Secretory Protein 2 (CRISP2) could be linked to the proposed …