Type 2 immunity mediates protective responses to helminths and pathological responses to
allergens, but it also has broad roles in the maintenance of tissue integrity, including wound …

Leukocyte recruitment from the vasculature into tissues is a crucial component of the
immune system but is also key to inflammatory disease. Chemokines are central to this …

The extracellular matrix (ECM) is a complex three-dimensional structure composed of
proteins, glycans, and proteoglycans, constituting a critical component of the tumor …

Chemokine-driven leukocyte recruitment is a key component of the immune response and of
various diseases. Therapeutically targeting the chemokine system in inflammatory disease …

Hyaluronan (HA) is a major component of peri-and extra-cellular matrices and plays
important roles in many biological processes such as cell adhesion, proliferation and …

Epigenetic marks do not follow the Mendelian laws of inheritance. The environment can alter
the epigenotype of an individual when exposed to different external stressors. In lactating …

Background Pseudomonas aeruginosa (PA) is an opportunistic pathogen that can cause
sight threatening infections in the eye and fatal infections in the cystic fibrosis airway …

Tumors in patients non-responsive to immunotherapy harbor a series of barriers that impede
the efficacy of effector T-cells. Consequently, therapeutically modulating the chemotaxis …

We aimed to investigate the use of free glycosaminoglycan profiles (GAGomes) and cfDNA
in plasma to differentiate between lung cancer and benign lung disease, in a cohort of 113 …

We have demonstrated that cisplatin (CP), an anticancer drug, showed a preference for
binding the sulfated-L-iduronic acid (SL-IdoA) unit over the sulfated-D-glucuronic acid unit of …