The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …

Hypoxia-inducible factors (HIFs) are broadly expressed in human cancers, and HIF1α and
HIF2α were previously suspected to promote tumour progression through largely …

Cellular senescence refers to a state of irreversible cell cycle arrest that can be induced by
various cellular stresses and is known to play a pivotal role in tumour suppression. While …

Developmental and environmental signals converge on cell cycle machinery to achieve
proper and flexible organogenesis under changing environments. Studies on the plant cell …

p53 is an important tumor suppressor gene, which is stimulated by cellular stress like
ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to …

The tumor suppressor protein p53 induces or represses the expression of a variety of target
genes involved in cell cycle control, senescence, and apoptosis in response to oncogenic or …

For more than 25 years, MDM2 and its homolog MDMX (also known as MDM4) have been
shown to exert oncogenic activity. These two proteins are best understood as negative …

Dental composite resins are biomaterials commonly used to aesthetically restore the
structure and function of teeth impaired by caries, erosion, or fracture. Residual monomers …

Cancers are rare because their evolution is actively restrained by a range of tumour
suppressors. Of these p53 seems unusually crucial as either it or its attendant upstream or …

This article presents a state-of-the-art review and analysis of literature studies on the
morphological structure, fabrication, cytotoxicity, and photocatalytic toxicity of zinc oxide …