Airway mucus is a complex viscoelastic gel that provides a defensive physical barrier and
shields the airway epithelium by trapping inhaled foreign pathogens and facilitating their …

Chronic lung disease determines the morbidity and mortality of cystic fibrosis (CF) patients.
The pulmonary immune response in CF is characterized by an early and non-resolving …

Acidification of phagosomes has been proposed to have a key role in the microbicidal
function of phagocytes. Here, we show that in alveolar macrophages the cystic fibrosis …

The primary function of neutrophils in host defense is to contain and eradicate invading
microbial pathogens. This is achieved through a series of swift and highly coordinated …

Acute lung injury (ALI) is due to an uncontrolled systemic inflammatory response resulting
from direct injury to the lung or indirect injury in the setting of a systemic process. Such …

The inability of neutrophils to eradicate Pseudomonas aeruginosa within the cystic fibrosis
(CF) airway eventually results in chronic infection by the bacteria in nearly 80 percent of …

Studies have endeavored to reconcile whether dysfunction of neutrophils in people with
cystic fibrosis (CF) is a result of the genetic defect or is secondary due to infection and …

Rationale: Cigarette smoke extract inhibits chloride secretion in human bronchial epithelial
cells. Oxidants decrease gene expression, protein expression, and function of the cystic …

Genetic defects in cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene
cause CF. Infants with CFTR mutations show a peribronchial neutrophil infiltration prior to …

Monocyte exposure to LPS induces a transient state in which these cells are refractory to
further endotoxin stimulation. This phenomenon, termed endotoxin tolerance (ET), is …