Commonalities between copper neurotoxicity and Alzheimer's disease
R Patel, M Aschner - Toxics, 2021 - mdpi.com
Alzheimer's disease, a highly prevalent form of dementia, targets neuron function beginning
from the hippocampal region and expanding outwards. Alzheimer's disease is caused by …
from the hippocampal region and expanding outwards. Alzheimer's disease is caused by …
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and
without Alzheimer disease (AD; n control= 13; n AD= 83) from the Knight Alzheimer Disease …
without Alzheimer disease (AD; n control= 13; n AD= 83) from the Knight Alzheimer Disease …
Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases
Identification of therapeutic targets from genome-wide association studies (GWAS) requires
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …
Emerging genetic complexity and rare genetic variants in neurodegenerative brain diseases
Abstract Knowledge of the molecular etiology of neurodegenerative brain diseases (NBD)
has substantially increased over the past three decades. Early genetic studies of NBD …
has substantially increased over the past three decades. Early genetic studies of NBD …
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk
Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid
(CSF) has been associated with Alzheimer's disease (AD). TREM2 plays a critical role in …
(CSF) has been associated with Alzheimer's disease (AD). TREM2 plays a critical role in …
A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain
Background Alzheimer's disease (AD) is the most common form of dementia. This
neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting …
neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting …
Comprehensive evaluation of deconvolution methods for human brain gene expression
Transcriptome deconvolution aims to estimate the cellular composition of an RNA sample
from its gene expression data, which in turn can be used to correct for composition …
from its gene expression data, which in turn can be used to correct for composition …
Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism
Alcohol exposure triggers changes in gene expression and biological pathways in human
brain. We explored alterations in gene expression in the Pre-Frontal Cortex (PFC) of 65 …
brain. We explored alterations in gene expression in the Pre-Frontal Cortex (PFC) of 65 …
TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers
Background Low frequency coding variants in TREM2 are associated with Alzheimer
disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between …
disease (AD) risk and cerebrospinal fluid (CSF) TREM2 protein levels are different between …
The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion
Apart from amyloid β deposition and tau neurofibrillary tangles, Alzheimer's disease (AD) is
a neurodegenerative disorder characterized by neuronal loss and astrocytosis in the …
a neurodegenerative disorder characterized by neuronal loss and astrocytosis in the …