Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …

Highlights•Colchicine binding site inhibitors (CBSIs) emerge as new generations of tubulin
inhibitors.•CBSIs are less susceptible to multidrug resistance than FDA-approved tubulin …

We present an operationally simple redox coupling for the synthesis of N-1 substituted
benzimidazoles using feedstock building block 2-nitroaniline derivatives as the precursors …

Of Nature's nearly 3000 unique monoterpene indole alkaloids derived from tryptophan,
those members belonging to the Aspidosperma and Strychnos families continue to impact …

Cardamonin is a polyphenolic natural product that has been shown to possess cytotoxic
activity against a variety of cancer cell lines. We previously reported the semi-synthesis of a …

The O-acetyl (or acetate) derivative of the Aspidosperma alkaloid Jerantinine A (JAa) elicits
anti-tumor activity against cancer cell lines including mammary carcinoma cell lines …

Indole alkaloids, predominantly found in plants, are a large group of natural product-derived
compounds characterized by a remarkable chemical diversity associated with significant …

Monoterpenoid indole alkaloids are structurally diverse natural products found in plants of
the family Apocynaceae. Among them, vincristine and its derivatives are well known for their …

Background Acute myeloid leukemia (AML) is a heterogenous hematological malignancy
with poor long-term survival. New drugs which improve the outcome of AML patients are …

A concise semi-synthesis of the Aspidosperma alkaloids,(−)-jerantinine A and (−)-
melodinine P, and derivatives thereof, is reported. The novel compounds were shown to …