In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Recent years have seen exciting progress across human embryo research, including new
methods for culturing embryos, transcriptional profiling of embryogenesis and gastrulation …

Early embryo development is a highly dynamic process that plays a crucial role in
determining the health and characteristics of an organism. For many years, embryonic and …

Here, we report that a chemical cocktail (LCDM: leukemia inhibitory factor [LIF], CHIR99021,
dimethinedene maleate [DiM], minocycline hydrochloride), previously developed for …

Human naïve pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts
termed blastoids upon switch to inductive medium. However, the underlying mechanisms …

Technologies to reproduce specific aspects of early mammalian embryogenesis in vitro
using stem cells have skyrocketed over the last several years. With these advances, we …

The totipotent embryo initiates transcription during zygotic or embryonic genome activation
(EGA, ZGA). ZGA occurs at the 8-cell stage in humans and its failure leads to developmental …

Human development is a highly coordinated process, with any abnormalities during the
early embryonic stages that can often have detrimental consequences. The complexity and …

Pluripotent stem cells (PSCs) are important for studying development and hold great
promise in regenerative medicine due to their ability to differentiate into various cell types. In …

Communication between the maternal endometrium and developing embryo/conceptus is
critical to support successful pregnancy to term. Particularly studying the peri-implantation …