The multi-factorial nature of clinical multidrug resistance in cancer
Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
MicroRNA in leukemia: Tumor suppressors and oncogenes with prognostic potential
R Mardani, MH Jafari Najaf Abadi… - Journal of cellular …, 2019 - Wiley Online Library
Leukemia is known as a progressive malignant disease, which destroys the blood‐forming
organs and results in adverse effects on the proliferation and development of leukocytes and …
organs and results in adverse effects on the proliferation and development of leukocytes and …
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance
Early-stage detection of leukemia is a critical determinant for successful treatment of the
disease and can increase the survival rate of leukemia patients. The factors limiting the …
disease and can increase the survival rate of leukemia patients. The factors limiting the …
Nanoplatform-based natural products co-delivery system to surmount cancer multidrug-resistant
Y Liang, ZY Liu, PY Wang, YJ Li, RR Wang… - Journal of Controlled …, 2021 - Elsevier
The emergence of multidrug resistance (MDR) in malignant tumors is the primary reason for
invalid chemotherapy. Antitumor drugs are often adversely affected by the MDR of tumor …
invalid chemotherapy. Antitumor drugs are often adversely affected by the MDR of tumor …
Clinical significance of microRNAs in hematologic malignancies and hematopoietic stem cell transplantation
A Sevcikova, I Fridrichova, N Nikolaieva, L Kalinkova… - Cancers, 2023 - mdpi.com
Simple Summary Dysregulated microRNA (miRNA) expression has been described in the
initiation and progression of a wide spectrum of hematologic malignancies. Moreover …
initiation and progression of a wide spectrum of hematologic malignancies. Moreover …
MicroRNA and alternative mRNA splicing events in cancer drug response/resistance: potent therapeutic targets
Cancer is a multifaceted disease that involves several molecular mechanisms including
changes in gene expression. Two important processes altered in cancer that lead to …
changes in gene expression. Two important processes altered in cancer that lead to …
The lncRNA TDRG1 promotes cell proliferation, migration and invasion by targeting miR-326 to regulate MAPK1 expression in cervical cancer
H Jiang, M Liang, Y Jiang, T Zhang, K Mo, S Su… - Cancer cell …, 2019 - Springer
Abstract Background Recently, lncRNA-Testis developmental related gene 1 (TDRG1) was
proved to be a key modulator in reproductive organ-related cancers. The biological role of …
proved to be a key modulator in reproductive organ-related cancers. The biological role of …
miRNA-221 promotes cutaneous squamous cell carcinoma progression by targeting PTEN
ZH Gong, F Zhou, C Shi, T Xiang, CK Zhou… - Cellular & molecular …, 2019 - Springer
Background Cutaneous squamous cell carcinoma (CSCC) is a common type of skin
malignancy. MicroRNA-221 (miRNA-221) is a critical non-coding RNA in tumor initiation and …
malignancy. MicroRNA-221 (miRNA-221) is a critical non-coding RNA in tumor initiation and …
Biomarkers and corresponding biosensors for childhood cancer diagnostics
A Gharehzadehshirazi, M Zarejousheghani, S Falahi… - Sensors, 2023 - mdpi.com
Although tremendous progress has been made in treating childhood cancer, it is still one of
the leading causes of death in children worldwide. Because cancer symptoms overlap with …
the leading causes of death in children worldwide. Because cancer symptoms overlap with …
The diverse oncogenic and tumor suppressor roles of microRNA-105 in cancer
J Li, Z Zhang, F Chen, T Hu, W Peng, Q Gu… - Frontiers in …, 2019 - frontiersin.org
MicroRNAs (miRNAs) are non-coding small RNA molecules that regulate gene expression
at the post-transcriptional/translational level. They act a considerable role not only in the …
at the post-transcriptional/translational level. They act a considerable role not only in the …