Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …

The quantum nature of electrons and nuclei is manifested in countless biological events
including the rearrangements of electrons in biochemical reactions, electron and proton …

Truncation and mutation of a poorly folded 39-residue peptide has produced 20-residue
constructs that are> 95% folded in water at physiological pH. These constructs optimize a …

The origins of our nearly ten‐year research program of chemical and biological
investigations into peptides based on homologated proteinogenic amino acids are …

The construction of complex protein folds relies on the precise conversion of a linear
polypeptide chain into a compact 3-dimensional structure. The interplay of forces that link …

Hemes remain one of the most visible and versatile classes of cofactors utilized in biology. 1
Since their discovery, the structural and functional aspects of heme proteins have fascinated …

▪ Abstract De novo protein design has recently emerged as an attractive approach for
studying the structure and function of proteins. This approach critically tests our …

With increasing structural information on proteins, the opportunity to understand physical
forces governing protein folding is also expanding. One of the significant non‐covalent …

De novo protein design has proven to be a powerful tool for understanding protein folding,
structure, and function. In this Account, we highlight aspects of our research on the design of …

Polyketides from actinomycete bacteria provide the basis for many valuable medicines, so
engineering genes for their biosynthesis to produce variant molecules holds promise for …