Protein homeostasis, or proteostasis, has an important regulatory role in cellular function.
Protein quality control mechanisms, including protein folding and protein degradation …

Tau protein is encoded in the microtubule-associated protein tau (MAPT) gene and
contributes to the stability of microtubules in axons. Despite of its basic isoelectric point and …

Background Alzheimer's disease (AD) is a severe neurodegenerative disorder that
progressively destroys cognitive skills. Exploring the mechanism underlying autophagic …

Cells regularly synthesize new proteins to replace old or damaged proteins. Deposition of
various aberrant proteins in specific brain regions leads to neurodegeneration and aging …

In eukaryotic cells, ubiquitination and proteasomal degradation is an essential mechanism
for regulating protein functions. For example, critical signaling proteins play their roles by …

The Ubiquitin Proteasome System (UPS) is responsible for the degradation of misfolded or
aggregated proteins via a multistep ATP-dependent proteolytic mechanism. This process …

Throughout their life cycles, cells are subject to a variety of stresses that lead to a
compromise between cell death and survival. Survival is partially provided by the cell …

The tau protein is a highly soluble and natively unfolded protein. Under pathological
conditions, tau undergoes multiple post-translational modifications (PTMs) and …

Emerging evidences suggest abundant expression of Carboxy terminus of Hsc70 Interacting
Protein or CHIP (alias STIP1 Homology and U–box Containing Protein 1 or STUB1) in …

To investigate the molecular interactions of sodium dodecyl sulfate (SDS) with human
ubiquitin and its unfolding mechanisms, a comparative study was conducted on the …