Dysregulation of TCTP in biological processes and diseases

UA Bommer, A Telerman - Cells, 2020 - mdpi.com
Translationally controlled tumor protein (TCTP), also called histamine releasing factor (HRF)
or fortilin, is a multifunctional protein present in almost all eukaryotic organisms. TCTP is …

The translational controlled tumour protein TCTP: biological functions and regulation

UA Bommer - TCTP/tpt1-Remodeling Signaling from Stem Cell to …, 2017 - Springer
Abstract The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called
P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein …

The mitochondrial enzyme pyruvate carboxylase restricts pancreatic β-cell senescence by blocking p53 activation

Y Yang, B Wang, H Dong, H Lin… - Proceedings of the …, 2024 - pnas.org
Defective glucose-stimulated insulin secretion (GSIS) and β-cell senescence are hallmarks
in diabetes. The mitochondrial enzyme pyruvate carboxylase (PC) has been shown to …

Activation of the sweet taste receptor, T1R3, by the artificial sweetener sucralose regulates the pulmonary endothelium

EO Harrington, A Vang, J Braza… - American Journal of …, 2018 - journals.physiology.org
A hallmark of acute respiratory distress syndrome (ARDS) is pulmonary vascular
permeability. In these settings, loss of barrier integrity is mediated by cell-contact …

Role of TCTP in cell biological and disease processes

UA Bommer, T Kawakami - Cells, 2021 - mdpi.com
Translationally controlled tumor protein (TCTP), also referred to as histamine-releasing
factor (HRF) or fortilin, is a multifunctional protein, expressed in essentially all eukaryotic …

Pancreatic islet APJ deletion reduces islet density and glucose tolerance in mice

S Han, EW Englander, GA Gomez, C Rastellini… - …, 2015 - academic.oup.com
Protection and replenishment of a functional pancreatic β-cell mass (BCM) are key goals of
all diabetes therapies. Apelin, a small regulatory peptide, is the endogenous ligand for the …

Translationally controlled tumor protein is a novel biological target for neurofibromatosis type 1-associated tumors

D Kobayashi, M Hirayama, Y Komohara… - Journal of Biological …, 2014 - ASBMB
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease that predisposes
individuals to develop benign neurofibromas and malignant peripheral nerve sheath tumors …

Characterization of the translationally controlled tumor protein (TCTP) interactome reveals novel binding partners in human cancer cells

S Li, M Chen, Q Xiong, J Zhang, Z Cui… - Journal of proteome …, 2016 - ACS Publications
Translationally controlled tumor protein (TCTP) is a highly conserved housekeeping protein
present in eukaryotic organisms. It is involved in regulating many fundamental processes …

TCTP is essential for cell proliferation and survival during CNS development

SH Chen, CH Lu, MJ Tsai - Cells, 2020 - mdpi.com
Translationally controlled tumor-associated protein (TCTP) has been implicated in cell
growth, proliferation, and apoptosis through interacting proteins. Although TCTP is …

Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing

JM Fulcher, AC Swensen, YC Chen… - …, 2023 - academic.oup.com
Altered prohormone processing, such as with proinsulin and pro-islet amyloid polypeptide
(proIAPP), has been reported as an important feature of prediabetes and diabetes …