Leukocyte trafficking to the small and large intestines is tightly controlled to maintain
intestinal immune homeostasis, mediate immune responses, and regulate inflammation. A …

Chemokines are a family of low molecular weight proteins with an essential role in leukocyte
trafficking during both homeostasis and inflammation. The CC class of chemokines consists …

The specific pathogenesis underlining inflammatory bowel disease (IBD) is very
complicated, and it is further more difficult to clearly explain the pathophysiology of 2 major …

Intestinal immune cell trafficking has been identified as a central event in the pathogenesis
of inflammatory bowel diseases (IBD). Intensive research on different aspects of the immune …

Murine intraepithelial γδ T cells include distinct tissue-protective cells selected by epithelial
butyrophilin-like (BTNL) heteromers. To determine whether this biology is conserved in …

The principal targets for anti-chemokine therapy in inflammatory bowel disease (IBD) have
been the receptors CCR9 and CXCR3 and their respective ligands CCL25 and CXCL10 …

Chemokine is a structure-related protein with a relatively small molecular weight, which can
target cells to chemotaxis and promote inflammatory response. Inflammation plays an …

Inflammatory bowel disease (IBD) is a group of chronic disorders of the gastrointestinal tract
comprising Crohn's disease (CD) and ulcerative colitis (UC). Their etiologies are unknown …

The traffic of the different types of immune cells is an important aspect in the immune
response. Chemokines are soluble peptides that are able to attract cells by interaction with …

CCL25-mediated activation of CCR9 is critical for mucosal lymphocyte recruitment to the
intestine. In immune-mediated liver injury complicating inflammatory bowel disease …