Pancreatic islets of Langerhans secrete hormones that are vital to the regulation of blood
glucose and are, therefore, a key focus of diabetes research. Purifying viable and functional …

Insufficient insulin secretion is a key component of both type 1 and type 2 diabetes. Since
insulin is released by the islets of Langerhans, obtaining viable and functional islets is …

The applicability of islet transplantation as treatment for type 1 diabetes is limited by renal
and islet toxicities of currently available immunosuppressants. We describe a novel …

Background. Purified tissue dissociation enzymes (TDEs) are critical to successful human
islet isolation required for clinical transplantation, but little is known about the characteristics …

Tissue dissociation enzymes are critical reagents that affect the yield and quality of human
pancreatic islets required for islet transplantation. The United States Food and Drug …

Human adipose-derived stromal/stem cells (ASCs) are an abundant, readily available
population of adult stem cells that reside in adipose tissue and that have a great potential …

The islets of Langerhans are dynamic structures that can change in size, number of cells,
and molecular function in response to physiological and pathological stress. Molecular cues …

In 2007, the islet community was notified that the collagenase product most commonly used
for human islet isolations contained bovine neural tissue contaminants. To minimize this …

Different factors have been reported to influence islet isolation outcome, but their importance
varies between studies and are hampered by the small sample sizes in most studies. The …

Pancreatic islet transplantation is a minimally invasive treatment that has the potential to
prevent diabetes after total pancreatectomy for benign disease (islet autotransplantation) …