Fluid transport in the brain

MK Rasmussen, H Mestre… - Physiological …, 2022 - journals.physiology.org
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response

JR Polimeni, LD Lewis - Progress in neurobiology, 2021 - Elsevier
Fast fMRI enables the detection of neural dynamics over timescales of hundreds of
milliseconds, suggesting it may provide a new avenue for studying subsecond neural …

Velocity‐selective arterial spin labeling perfusion MRI: a review of the state of the art and recommendations for clinical implementation

Q Qin, DC Alsop, DS Bolar… - Magnetic resonance …, 2022 - Wiley Online Library
This review article provides an overview of the current status of velocity‐selective arterial
spin labeling (VSASL) perfusion MRI and is part of a wider effort arising from the …

[HTML][HTML] AMPK-regulated astrocytic lactate shuttle plays a non-cell-autonomous role in neuronal survival

R Muraleedharan, MV Gawali, D Tiwari, A Sukumaran… - Cell reports, 2020 - cell.com
Lactate is used as an energy source by producer cells or shuttled to neighboring cells and
tissues. Both glucose and lactate fulfill the bioenergetic demand of neurons, the latter …

[HTML][HTML] Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI

AP Fan, H An, F Moradi, J Rosenberg, Y Ishii, T Nariai… - Neuroimage, 2020 - Elsevier
Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO 2) are
key cerebral physiological parameters to identify at-risk cerebrovascular patients and …

Cerebral oxygen extraction fraction MRI: Techniques and applications

D Jiang, H Lu - Magnetic resonance in medicine, 2022 - Wiley Online Library
The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …

[HTML][HTML] A dynamical model of the laminar BOLD response

M Havlicek, K Uludağ - NeuroImage, 2020 - Elsevier
High-resolution functional magnetic resonance imaging (fMRI) using blood oxygenation
dependent level-dependent (BOLD) signal is an increasingly popular tool to non-invasively …

Separating vascular and neuronal effects of age on fMRI BOLD signals

KA Tsvetanov, RNA Henson… - … Transactions of the …, 2021 - royalsocietypublishing.org
Accurate identification of brain function is necessary to understand the neurobiology of
cognitive ageing, and thereby promote well-being across the lifespan. A common tool used …

[HTML][HTML] Functional MRI of brain physiology in aging and neurodegenerative diseases

JJ Chen - Neuroimage, 2019 - Elsevier
Brain aging and associated neurodegeneration constitute a major societal challenge as well
as one for the neuroimaging community. A full understanding of the physiological …

Phase dual‐slopes in frequency‐domain near‐infrared spectroscopy for enhanced sensitivity to brain tissue: First applications to human subjects

G Blaney, A Sassaroli, T Pham… - Journal of …, 2020 - Wiley Online Library
We present a first in vivo application of phase dual‐slopes (DSϕ), measured with frequency‐
domain near‐infrared spectroscopy on four healthy human subjects, to demonstrate their …