Acid sphingomyelinase (ASM) cleaves sphingomyelin into the highly lipophilic ceramide,
which forms large gel-like rafts/platforms in the plasma membrane. We showed that SARS …

Sphingolipid metabolites participate in key events of signal transduction and cell regulation.
In the sphingomyelin cycle, a number of extracellular agents and insults (such as tumor …

Lysosomal membrane permeabilization and subsequent cell death may prove useful in
cancer treatment, provided that cancer cell lysosomes can be specifically targeted. Here, we …

Lysosomes are acidic organelles that contain hydrolytic enzymes that mediate the
intracellular degradation of macromolecules. Damage of these organelles often results in …

The drug efflux pump P‐glycoprotein (P‐gp) plays an important role in the function of the
blood–brain barrier by selectively extruding certain endogenous and exogenous molecules …

Some organic weak bases induce a detachment from inner lysosomal membranes and
subsequent inactivation of acid sphingomyelinase (ASM) and thus work as functional ASM …

Non-small cell lung cancer (NSCLC) is one of the deadliest cancers worldwide. In search for
new NSCLC treatment options, we screened a cationic amphiphilic drug (CAD) library for …

Acquired therapy resistance is one of the prime obstacles for successful cancer treatment.
Partial resistance is often acquired already during an early face of tumor development when …

We have previously shown that multidrug-resistant cancer cells display elevated levels of
glucosylceramide (Lavie, Y., Cao, H., Bursten, SL, Giuliano, AE, and Cabot, MC (1996) J …

A major lipid signalling pathway in mammalian cells implicates the activation of
sphingomyelinase (SMase), which upon cell stimulation hydrolyses the ubiquitous …