Cells within cells: Rickettsiales and the obligate intracellular bacterial lifestyle

J Salje - Nature Reviews Microbiology, 2021 - nature.com
The Rickettsiales are a group of obligate intracellular vector-borne Gram-negative bacteria
that include many organisms of clinical and agricultural importance, including Anaplasma …

Engineering of obligate intracellular bacteria: progress, challenges and paradigms

EE McClure, ASO Chávez, DK Shaw… - Nature Reviews …, 2017 - nature.com
It is estimated that approximately one billion people are at risk of infection with obligate
intracellular bacteria, but little is known about the underlying mechanisms that govern their …

Recent advances in genetic systems in obligate intracellular human-pathogenic bacteria

DJ Fisher, PA Beare - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
The ability to genetically manipulate a pathogen is fundamental to discovering factors
governing host–pathogen interactions at the molecular level and is critical for devising …

Pathogenic Rickettsia spp. as emerging models for bacterial biology

B Sit, RL Lamason - Journal of Bacteriology, 2024 - Am Soc Microbiol
Our understanding of free-living bacterial models like Escherichia coli far outpaces that of
obligate intracellular bacteria, which cannot be cultured axenically. All obligate intracellular …

The neglected challenge: Vaccination against rickettsiae

A Osterloh - PLoS neglected tropical diseases, 2020 - journals.plos.org
Over the last decades, rickettsioses are emerging worldwide. These diseases are caused by
intracellular bacteria. Although rickettsioses can be treated with antibiotics, a vaccine …

Development of inducible promoter and CRISPRi plasmids functional in Rickettsia rickettsii

AM Nock, TR Clark, T Hackstadt - Journal of Bacteriology, 2024 - journals.asm.org
Rickettsia rickettsii is an obligate intracellular, tick-borne bacterium that causes Rocky
Mountain spotted fever. The demanding nature of cultivating these bacteria within host cells …

Peptide Nucleic Acid Knockdown and Intra-host Cell Complementation of Ehrlichia Type IV Secretion System Effector

P Sharma, O Teymournejad, Y Rikihisa - Frontiers in cellular and …, 2017 - frontiersin.org
Survival of Ehrlichia chaffeensis depends on obligatory intracellular infection. One of the
barriers to E. chaffeensis research progress has been the inability, using conventional …

Orientia tsutsugamushi: A life between escapes

L Fromm, J Mehl, C Keller - MicrobiologyOpen, 2023 - Wiley Online Library
To replicate within host cells, intracellular bacteria have evolved different strategies to
invade, replicate, persist in, and eventually exit from their hosts. The intracellular lifestyle …

Examination of Rickettsial Host Range for Shuttle Vectors Based on dnaA and parA Genes from the pRM Plasmid of Rickettsia monacensis

NY Burkhardt, LD Price, XR Wang… - Applied and …, 2022 - Am Soc Microbiol
The genus Rickettsia encompasses a diverse group of obligate intracellular bacteria that are
highly virulent disease agents of mankind as well as symbionts of arthropods. Native …

Transmission of Amblyomma maculatum-Associated Rickettsia spp. During Cofeeding on Cattle

JK Lee, JV Stokes, GM Moraru, AB Harper… - Vector-Borne and …, 2018 - liebertpub.com
Amblyomma maculatum is the primary vector for the spotted fever group rickettsiae,
Rickettsia parkeri, a known pathogen, and “Candidatus Rickettsia andeanae,” currently …