Circulating cell-free DNA-based methylation pattern in saliva for early diagnosis of head and neck cancer

N Birknerova, V Mancikova, ED Paul, J Matyasovsky… - Cancers, 2022 - mdpi.com
Simple Summary Liquid biopsy represents a promising alternative to standard-of-care tissue
biopsies, outperforming the latter in several aspects: invasiveness, cost, spatial limitation to …

Molecular tumor subtypes of HPV-positive head and neck cancers: biological characteristics and implications for clinical outcomes

T Qin, S Li, LE Henry, S Liu, MA Sartor - Cancers, 2021 - mdpi.com
Simple Summary Human papillomavirus (HPV) infections are responsible for a continually
growing number of head and neck cancer (HNC) cases, with the incident rate overtaking that …

HPV infection and 5mC/5hmC epigenetic markers in penile squamous cell carcinoma: new insights into prognostics

RS Santos, CG Hirth, DP Pinheiro, MJB Bezerra… - Clinical …, 2022 - Springer
Background Penile cancer is one of the most aggressive male tumors. Although it is
preventable, the main etiologic causes are lifestyle behaviors and viral infection, such as …

Epigenetic and transcriptomic regulation landscape in HPV+ cancers: biological and clinical implications

R Castro-Oropeza, P Piña-Sánchez - Frontiers in Genetics, 2022 - frontiersin.org
Human Papillomavirus (HPV) is an oncogenic virus that causes the highest number of viral-
associated cancer cases and deaths worldwide, with more than 690,000 new cases per year …

Whole-genome CpG-resolution DNA Methylation Profiling of HNSCC Reveals Distinct Mechanisms of Carcinogenesis for Fine-scale HPV+ Cancer Subtypes

T Qin, S Li, LE Henry, E Chou, RG Cavalcante… - Cancer Research …, 2023 - AACR
DNA methylation is a vital early step in carcinogenesis. Most findings of aberrant DNA
methylation in head and neck squamous cell carcinomas (HNSCC) are array based with …

Epigenetic regulations of perineural invasion in head and neck squamous cell carcinoma

P Hurník, Z Chyra, T Ševčíková, J Štembírek… - Frontiers in …, 2022 - frontiersin.org
Carcinomas of the oral cavity and oropharynx belong among the ten most common
malignancies in the human population. The prognosis of head and neck squamous cell …

Unidirectional alteration of methylation and hydroxymethylation at the promoters and differential gene expression in oral squamous cell carcinoma

W Zhao, L Zhu, Q Gong, S Ma, H Xiong, T Su… - Frontiers in …, 2023 - frontiersin.org
Background: Oral squamous cell carcinoma (OSCC) is one of the most common types of
cancer worldwide. Although overall losses of 5-methylcytosine (5mC) and 5 …

[HTML][HTML] Changes in DNA methylation profile in liver tissue during progression of HCV-induced fibrosis to hepatocellular carcinoma

IA Goncharova, AA Zarubin… - Vavilov Journal of …, 2023 - ncbi.nlm.nih.gov
In this study we compared methylation levels of 27,578 CpG sites between paired samples
of the tumor and surrounding liver tissues with various degrees of damage (fibrosis …

[HTML][HTML] Tumor Subtype Classification Tool for HPV-associated Head and Neck Cancers

S Li, BF Garb, T Qin, S Soppe, E Lopez, S Patil… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Objective To develop a robust, accurate machine learning-based classification tool that
standardizes the process of subtyping HPV+ HNSCC, and to investigate the clinical …

Изменение профиля метилирования ДНК в ткани печени при прогрессировании HCV-индуцированного фиброза до гепатоцеллюлярной карциномы

ИА Гончарова, АА Зарубин… - … журнал генетики и …, 2023 - vavilov.elpub.ru
Аннотация С использованием данных GSE73003 и GSE37988, представленных в базе
данных GEODataSets (https://www. ncbi. nlm. nih. gov/), проведен сравнительный анализ …