Perturbations of the endolysosomal pathway have been suggested to play an important role
in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease …

The vacuolar protein sorting 35 ortholog (VPS35) gene encodes a core component of the
retromer complex essential for the endosomal sorting and recycling of transmembrane …

Retromer controls cellular homeostasis through regulating integral membrane protein
sorting and transport and by controlling maturation of the endo-lysosomal network. Retromer …

Retromer is a heteropentameric complex that plays a specialized role in endosomal protein
sorting and trafficking. Here, we report a reduction in the retromer proteins—vacuolar protein …

Background Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene cause late-
onset, autosomal dominant Parkinson's disease (PD), with a single missense mutation …

Retromer is a highly integrated multimeric protein complex that mediates retrograde cargo
sorting from endosomal compartments. In concert with its accessory proteins, the retromer …

Cognitive dysfunction is a salient feature of Parkinson's disease (PD) and Dementia with
Lewy bodies (DLB). The onset of dementia reflects the spread of Lewy pathology throughout …

Background Beta-amyloid (Aβ) deposition in the brain parenchyma is a crucial initiating step
in the amyloid cascade hypothesis of Alzheimer's disease (AD) pathology. Furthermore …

Background: Blood-brain barrier (BBB) breakdown is a crucial aspect of Alzheimer's disease
(AD) progression. Dysfunction in BBB is primarily caused by impaired tight junction and …

Background In the present study we assessed the protective effects of a pharmacological
approach to stabilize the retromer complex in a PD mouse model. Missense mutations in the …