Hereditary spastic paraplegia (HSP) is a syndrome designation describing inherited
disorders in which lower extremity weakness and spasticity are the predominant symptoms …

Many major human neurodegenerative diseases, including Alzheimer's disease,
Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies …

INTRODUCTION The microtubule cytoskeleton is continuously sculpted by polymerization,
depolymerization, cross-linking, and microtubule severing. Microtubule severing generates …

Microtubule-severing enzymes are critical for the biogenesis and maintenance of complex
microtubule arrays in axons, spindles, and cilia where tubulin detyrosination, acetylation …

Hereditary spastic paraplegia (HSP) describes a heterogeneous group of genetic
neurodegenerative disorders in which the most severely affected neurons are those of the …

Microtubules create diverse arrays with specific cellular functions such as the mitotic spindle,
cilia, and bundles inside neurons. How microtubules are regulated to enable specific …

Microtubule-severing enzymes generate internal breaks in microtubules. They are
conserved in eukaryotes from ciliates to mammals, and their function is important in diverse …

All microtubules are built from a basic α/β-tubulin building block, yet subpopulations of
microtubules can be differentially marked by a number of post-translational modifications …

Microtubules give rise to intracellular structures with diverse morphologies and dynamics
that are crucial for cell division, motility, and differentiation. They are decorated with …

Posttranslational glutamylation of tubulin is present on selected subsets of microtubules in
cells. Although the modification is expected to contribute to the spatial and temporal …