Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen
species (ROS) and improves nitric oxide bioavailability. It has been studied extensively in …

The antioxidant tempol reduces obesity in mice. Here we show that tempol alters the gut
microbiome by preferentially reducing the genus Lactobacillus and its bile salt hydrolase …

Background—Digital pulse amplitude augmentation in response to hyperemia is a novel
measure of peripheral vasodilator function that depends partially on endothelium-derived …

Over two-thirds of individuals aged 65 and older are obese or overweight in the United
States. Epidemiological data show an association between the degree of adiposity and …

Obesity is a metabolic disorder of increasing prevalence worldwide and a risk factor for the
development of insulin resistance (IR), metabolic syndrome and type 2 diabetes. Obesity is …

[Frontiers in Bioscience 16, 1733-1745, January 1, 2011] 1733 Oxidative stress and endothelial
dysfunction in cerebrovascular di Page 1 [Frontiers in Bioscience 16, 1733-1745, January 1 …

One of the most profound challenges facing public health and public health policy in
Western society is the increased incidence and prevalence of both overweight and obesity …

Endothelial cells exert an enormous influence on blood vessels throughout the circulation,
but their impact is particularly pronounced in the brain. New concepts have emerged …

The study of reactive oxygen species (ROS) and oxidative stress remains a very active area
of biological research, particularly in relation to cellular signaling and the role of ROS in …