The discovery of clonal hematopoiesis (CH) in older individuals has changed the way
hematologists and stem cell biologists view aging. Somatic mutations accumulate in stem …

Somatic Mutations in “Benign” Disease DNA mutations occur in nearly every tissue
throughout the human life span and accumulate at various rates in different tissues …

Large-scale sequencing has enabled unparalleled opportunities to investigate the role of
rare coding variation in human phenotypic variability. Here, we present a pan-ancestry …

Background Clonal hematopoiesis of indeterminate potential (CHIP) is an inflammatory
premalignant disorder resulting from acquired genetic mutations in hematopoietic stem cells …

Clonal hematopoiesis (CH) is an aging-associated condition characterized by the clonal
outgrowth of mutated preleukemic cells. Individuals with CH are at an increased risk of …

Telomeres protect chromosome ends from damage and their length is linked with human
disease and aging. We developed a joint telomere length metric, combining quantitative …

PURPOSE To prospectively examine the association between clonal hematopoiesis (CH)
and subsequent risk of lung cancer. METHODS Among 200,629 UK Biobank (UKBB) …

Current recommended risk scores to predict thrombotic events associated with
myeloproliferative neoplasms (MPN) do not discriminate between arterial and venous …

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the expansion of
hematopoietic cells harboring leukemia-associated somatic mutations in otherwise healthy …

Our knowledge of how clonal hematopoiesis relates to diverse health conditions has grown
vastly over the past years, touching upon many specialties beyond cancer medicine. Given …