The characteristics and roles of β‐TrCP1/2 in carcinogenesis
Y Bi, D Cui, X Xiong, Y Zhao - The FEBS journal, 2021 - Wiley Online Library
β‐transducin repeat‐containing protein (β‐TrCP), one of the well‐characterized F‐box
proteins, acts as a substrate receptor and constitutes an active SCFβ‐TrCP E3 ligase with a …
proteins, acts as a substrate receptor and constitutes an active SCFβ‐TrCP E3 ligase with a …
Regulation of mitogen-activated protein kinase signaling pathways by the ubiquitin-proteasome system and its pharmacological potential
S Mathien, C Tesnière, S Meloche - Pharmacological Reviews, 2021 - ASPET
Mitogen-activated protein kinase (MAPK) cascades are evolutionarily conserved signaling
pathways that play essential roles in transducing extracellular environmental signals into …
pathways that play essential roles in transducing extracellular environmental signals into …
[PDF][PDF] Methionine adenosyltransferase α1 is targeted to the mitochondrial matrix and interacts with cytochrome P450 2E1 to lower its expression
B Murray, H Peng, L Barbier‐Torres, AE Robinson… - …, 2019 - Wiley Online Library
Methionine adenosyltransferase α1 (MATα1, encoded by MAT1A) is responsible for hepatic
biosynthesis of S‐adenosyl methionine, the principal methyl donor. MATα1 also act as a …
biosynthesis of S‐adenosyl methionine, the principal methyl donor. MATα1 also act as a …
[HTML][HTML] PUMA overexpression dissociates thioredoxin from ASK1 to activate the JNK/BCL-2/BCL-XL pathway augmenting apoptosis in ovarian cancer
Y Chen, N Li, J Yang, K Li, M Tang, X Zhao… - … et Biophysica Acta (BBA …, 2022 - Elsevier
ASK1-JNK signaling promotes mitochondrial dysfunction-mediated apoptosis, but the bridge
between JNK and apoptosis is not fully understood. PUMA induces apoptosis through …
between JNK and apoptosis is not fully understood. PUMA induces apoptosis through …
[PDF][PDF] F‐box/WD repeat‐containing protein 5 mediates the ubiquitination of apoptosis signal‐regulating kinase 1 and exacerbates nonalcoholic steatohepatitis in mice
L Bai, MM Chen, ZD Chen, P Zhang, S Tian… - …, 2019 - Wiley Online Library
Inhibition of apoptosis signal‐regulating kinase 1 (ASK1) activation has emerged as a
promising target for the treatment of nonalcoholic steatohepatitis (NASH). Multiple forms of …
promising target for the treatment of nonalcoholic steatohepatitis (NASH). Multiple forms of …
Discovery and development of ASK1 inhibitors
R Brys, K Gibson, T Poljak, S Van Der Plas… - Progress in Medicinal …, 2020 - Elsevier
Aberrant activation of mitogen-activated protein kinases (MAPKs) like c-Jun N-terminal
kinase (JNK) and p38 is an event involved in the pathophysiology of numerous human …
kinase (JNK) and p38 is an event involved in the pathophysiology of numerous human …
[HTML][HTML] Therapeutic potential of ASK1 activators in cancer treatment: Current insights and future directions
B Wang, Y Ma, Y Zhang, X Yin - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Apoptosis signal-regulated kinase 1 (ASK1) is a member of the mitogen-activated protein
kinase kinase (MAP3K) family, whose activation and regulation are intricately associated …
kinase kinase (MAP3K) family, whose activation and regulation are intricately associated …
[HTML][HTML] The E3 ubiquitin ligase Slimb/β-TrCP is required for normal copper homeostasis in Drosophila
B Zhang, T Binks, R Burke - … et Biophysica Acta (BBA)-Molecular Cell …, 2020 - Elsevier
Abstract The Drosophila Slimb (Slmb) gene encodes a Skp1-Cul1-F-box (SCP) E3 ubiquitin
ligase orthologous to the human β-TrCP/BTRC protein. Slmb and/or BTRC play regulatory …
ligase orthologous to the human β-TrCP/BTRC protein. Slmb and/or BTRC play regulatory …
miR-200b-3p antagomir inhibits neuronal apoptosis in oxygen-glucose deprivation (OGD) model through regulating β-TrCP
N Zhang, L Yang, J Wen, H Cui - Brain Research, 2023 - Elsevier
Background Hypoxia-ischemic brain damage (HIBD) is a primary cause of morbidity and
disability in survivors of preterm infants. We previously discovered that miR-200b-3p plays …
disability in survivors of preterm infants. We previously discovered that miR-200b-3p plays …
[HTML][HTML] ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes
S Takayanagi, K Watanabe, T Maruyama, M Ogawa… - Scientific reports, 2021 - nature.com
Recent studies have shown that adipose tissue is an immunological organ. While
inflammation in energy-storing white adipose tissues has been the focus of intense …
inflammation in energy-storing white adipose tissues has been the focus of intense …