Peptide-mimicking poly (2-oxazoline) s possessing potent antifungal activity and BBB penetrating property to treat invasive infections and meningitis
Invasive fungal infections, including meningitis, cause a high mortality rate due to few
available antifungal drugs and frequently associated side effects and quick emergence of …
available antifungal drugs and frequently associated side effects and quick emergence of …
Facially Amphiphilic Bile Acid-Functionalized Antimicrobials: Combating Pathogenic Bacteria, Fungi, and Their Biofilms
We report facially amphiphilic bile acid-based antimicrobials with a broad spectrum of
activity against both bacterial and fungal pathogens and negligible detrimental effects on …
activity against both bacterial and fungal pathogens and negligible detrimental effects on …
Development of Phloroglucinol-Linked Tris-Quaternary Ammonium Salt Antimicrobial Peptide Mimics with Low Cytotoxicity and Broad-Spectrum Antibacterial Activity
D Yan, H Kong, Y Qu, R Li… - Journal of Medicinal …, 2024 - ACS Publications
Encouraged by the significantly different toxicities and antibacterial activities of diverse
linkers, such as alkyl and aromatic nuclei linkers, and the unique structure of phloroglucinol …
linkers, such as alkyl and aromatic nuclei linkers, and the unique structure of phloroglucinol …
Confronting the Threat: Designing Highly Effective bis-Benzimidazolium Agents to Overcome Biofilm Persistence and Antimicrobial Resistance
M Petit, J Tessier, C Sahli… - ACS Infectious Diseases, 2023 - ACS Publications
The objective of this study is to take the initial steps toward developing novel antibiotics to
counteract the escalating problem of antimicrobial and bacterial persistence, particularly in …
counteract the escalating problem of antimicrobial and bacterial persistence, particularly in …
Effective ciprofloxacin cationic antibacterial agent against persister bacteria with low hemolytic toxicity
C Gao, S Qin, M Wang, R Li… - European Journal of …, 2024 - Elsevier
With the widespread use of antibiotics, bacterial resistance has developed rapidly. To make
matters worse, infections caused by persistent bacteria and biofilms often cannot be …
matters worse, infections caused by persistent bacteria and biofilms often cannot be …
Synthesis of Positional Isomers and Photophysical Properties of Pyridines with Tricyanobutadiene Fragment Containing Aryl and Trifluoromethyl Substituents
MA Shishlikova, OV Ershov - Russian Journal of General Chemistry, 2024 - Springer
A method was developed for obtaining positional isomers—2-[6-aryl-4-trifluoromethyl-3-
cyanopyridin-2 (1 H)-ylidene] malononitriles and 2-[4-aryl-6-trifluoromethyl-3-cyanopyridin-2 …
cyanopyridin-2 (1 H)-ylidene] malononitriles and 2-[4-aryl-6-trifluoromethyl-3-cyanopyridin-2 …
New insight in cyclic monoterpenoids mechanism of action: an in silico approach
Clarifying the mechanism of action of natural terpenoids is challenging. Further, their efficacy
is inspiring in developing new antimycotic agents. Among all, thymol, carvacrol and thymyl …
is inspiring in developing new antimycotic agents. Among all, thymol, carvacrol and thymyl …