The development of novel synthetic strategies to form new chemical entities in a
stereoselective manner is an ongoing significant objective in organic and medicinal …

First reported less than a decade ago, the α, β-unsaturated acyl azolium has emerged as a
central reactive intermediate for reaction discovery using N-heterocyclic carbene catalysis …

Over the past decade, the catalysis of N-heterocyclic carbenes has achieved significant
advances. In this area, aldehydes, enals, and esters, are commonly employed as starting …

Amides are among the most fundamental functional groups and essential structural units,
widely used in chemistry, biochemistry and material science. Amide synthesis and …

A mild and environmentally friendly carbene-catalyzed aerobic oxidation of isoquinolinium
salts was successfully realized. Accordingly, a diverse set of isoquinolinones and …

In the last ten years, the combination of Lewis acid with N-heterocyclic carbene (NHC)
catalysis has emerged as a powerful strategy in a variety of important asymmetric synthesis …

Herein, an efficient route to enantioenriched organosilanes, containing two consecutive
stereogenic centers, from enals and β‐silyl enones under carbene organocatalysis is …

An unprecedented N-heterocyclic carbene (NHC)-catalyzed enantioselective [3+ 2]
annulation of enals with vinyl ketones has been achieved. Unlike chalcones, the β …

The copper-catalyzed [4+ 2] annulation of α, β-unsaturated ketoxime acetates with 1, 3-
dicarbonyl compounds for the synthesis of three classes of structurally diverse pyridines has …

A novel strategy for the construction of 2, 2-diacyl spirocyclohexanones 3 has been
demonstrated on the basis of an NHC-catalyzed [3C+ 3C] annulation of potassium 2-oxo-3 …