Gram-positive organisms, including the pathogens Staphylococcus aureus, Streptococcus
pneumoniae, and Enterococcus faecalis, have dynamic cell envelopes that mediate …

The biosynthesis of bacterial cell wall peptidoglycan is a complex process that involves
enzyme reactions that take place in the cytoplasm (synthesis of the nucleotide precursors) …

Peptidoglycan is a defining feature of the bacterial cell wall. Initially identified as a target of
the revolutionary beta-lactam antibiotics, peptidoglycan has become a subject of much …

The bacterial cell wall is a complex, mesh-like structure that in most bacteria is essential for
maintenance of cell shape and structural integrity. Historically, the cell wall has been of …

Streptococcus pneumoniae (pneumococcus) is a leading human respiratory pathogen that
causes a variety of serious mucosal and invasive diseases. D39 is an historically important …

One of the biggest challenges for recent medical research is the continuous development of
new antibiotics interacting with bacterial essential mechanisms. The machinery for …

2.2 Phosphoglucosamine mutase 2.3 GlmU synthase 3 Formation of UDP-N-acetylmuramic
acid 3.1 Transferase MurA 3.2 MurB reductase 4 Formation of UDP-MurNAc-peptides 4.1 …

Bacterial infections caused by antibiotic-resistant isolates have become a major health
problem in recent years, since they are very difficult to treat, leading to an increase in …

The molecular events following inhibition of bacterial peptidoglycan synthesis have not been
studied extensively. Previous proteomic studies have revealed that certain proteins are …

Background UDP-N-acetylglucosamine enolpyruvyl transferase (MurA), catalyses the first
committed step of bacterial cell wall biosynthesis and is a target for the antibiotic fosfomycin …