Transmembrane TNF-α, a precursor of the soluble form of TNF-α, is expressed on activated
macrophages and lymphocytes as well as other cell types. After processing by TNF-α …

One of the functions of the immune system is to recognize and destroy abnormal or infected
cells to maintain homeostasis. This is accomplished by cytotoxic lymphocytes. Cytotoxicity is …

Adoptive cell transfer (ACT) of purified naive, stem cell memory, and central memory T cell
subsets results in superior persistence and antitumor immunity compared with ACT of …

The CD95 Receptor: Apoptosis Revisited: Cell Skip to Main Content Advertisement Cell This
journal offers authors two options (open access or subscription) to publish research Submit Log …

The apoptosis-inducing Fas ligand (FasL) is a type II transmembrane protein that is involved
in the downregulation of immune reactions by activation-induced cell death (AICD) as well …

Recent evidence shows that many molecules of the TNF family serve as counter-receptors,
inducing costimulation through reverse signals in addition to delivering signals through their …

Fas ligand (FasL) is a type II transmembrane protein belonging to the tumor necrosis factor
family. Its binding to the cognate Fas receptor triggers the apoptosis that plays a pivotal role …

TNF-related ligands (with the exception of lymphotoxin-α) are synthesized as type II
transmembrane proteins, though many of them also have soluble forms. An increasing …

Abstract CD95 (Fas/APO-1) is a multifunctional cell surface receptor with antithetic roles.
First described to mediate cell death, interactions of CD95 with its natural ligand, CD95L …

The role of costimulation has previously been confined to the very early stages of the CD8+
T cell response. In this study, we demonstrate the requirement for CD27 costimulation during …