Lipids are abundant and play essential roles in human health and disease. The main
functions of lipids are building blocks for membrane biogenesis. However, lipids are also …

Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …

BACKGROUND Reprogramming of host metabolism supports viral pathogenesis by fueling
viral proliferation, by providing, for example, free amino acids and fatty acids as building …

The SARS-CoV-2 beta coronavirus is the etiological driver of COVID-19 disease, which is
primarily characterized by shortness of breath, persistent dry cough, and fever. Because they …

Extreme hypoxia of tumors represents the most notable barrier against the advance of tumor
treatments. Inspired by the biological nature of red blood cells (RBCs) as the primary oxygen …

Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …

Non-invasive sonodynamic therapy (SDT) was developed because of its advantages of high
penetration depth and low side effects; however, tumor hypoxia greatly restricts its …

Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field
of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin …

A supramolecular organic framework (SOF) was fabricated based on the
tetraphenylethylene derivative MV-TPE with four methylated viologen units …

The hypoxic tumor microenvironment is characterized by disordered vasculature and rapid
proliferation of tumors, resulting from tumor invasion, progression and metastasis. The …