The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA
V Barra, D Fachinetti - Nature communications, 2018 - nature.com
Centromeres are the chromosomal domains required to ensure faithful transmission of the
genome during cell division. They have a central role in preventing aneuploidy, by …
genome during cell division. They have a central role in preventing aneuploidy, by …
Guarding the genome: CENP-A-chromatin in health and cancer
MA Mahlke, Y Nechemia-Arbely - Genes, 2020 - mdpi.com
Faithful chromosome segregation is essential for the maintenance of genomic integrity and
requires functional centromeres. Centromeres are epigenetically defined by the histone H3 …
requires functional centromeres. Centromeres are epigenetically defined by the histone H3 …
[HTML][HTML] Mutational strand asymmetries in cancer genomes reveal mechanisms of DNA damage and repair
Mutational processes constantly shape the somatic genome, leading to immunity, aging,
cancer, and other diseases. When cancer is the outcome, we are afforded a glimpse into …
cancer, and other diseases. When cancer is the outcome, we are afforded a glimpse into …
Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition
SA Lujan, AR Clausen, AB Clark… - Genome …, 2014 - genome.cshlp.org
Mutational heterogeneity must be taken into account when reconstructing evolutionary
histories, calibrating molecular clocks, and predicting links between genes and disease …
histories, calibrating molecular clocks, and predicting links between genes and disease …
Genome plasticity in Candida albicans is driven by long repeat sequences
Genome rearrangements resulting in copy number variation (CNV) and loss of
heterozygosity (LOH) are frequently observed during the somatic evolution of cancer and …
heterozygosity (LOH) are frequently observed during the somatic evolution of cancer and …
Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment
Centromeres play several important roles in ensuring proper chromosome segregation. Not
only do they promote kinetochore assembly for microtubule attachment, but they also …
only do they promote kinetochore assembly for microtubule attachment, but they also …
Chromosome engineering allows the efficient isolation of vertebrate neocentromeres
WH Shang, T Hori, NMC Martins, A Toyoda, S Misu… - Developmental cell, 2013 - cell.com
Centromeres are specified by sequence-independent epigenetic mechanisms in most
organisms. Rarely, centromere repositioning results in neocentromere formation at ectopic …
organisms. Rarely, centromere repositioning results in neocentromere formation at ectopic …
Histone modifications rather than the novel regional centromeres of Zymoseptoria tritici distinguish core and accessory chromosomes
K Schotanus, JL Soyer, LR Connolly… - Epigenetics & …, 2015 - Springer
Background Supernumerary chromosomes have been found in many organisms. In fungi,
these “accessory” or “dispensable” chromosomes are present at different frequencies in …
these “accessory” or “dispensable” chromosomes are present at different frequencies in …
Assembly of a phased diploid Candida albicansgenome facilitates allele-specific measurements and provides a simple model for repeat and indel structure
Background Candida albicans is a ubiquitous opportunistic fungal pathogen that afflicts
immunocompromised human hosts. With rare and transient exceptions the yeast is diploid …
immunocompromised human hosts. With rare and transient exceptions the yeast is diploid …
Genomic and epigenetic foundations of neocentromere formation
EM DeBose-Scarlett, BA Sullivan - Annual review of genetics, 2021 - annualreviews.org
Centromeres are essential to genome inheritance, serving as the site of kinetochore
assembly and coordinating chromosome segregation during cell division. Abnormal …
assembly and coordinating chromosome segregation during cell division. Abnormal …