Overcoming negatively charged tissue barriers: Drug delivery using cationic peptides and proteins
Negatively charged tissues are ubiquitous in the human body and are associated with a
number of common diseases yet remain an outstanding challenge for targeted drug delivery …
number of common diseases yet remain an outstanding challenge for targeted drug delivery …
Cystic fibrosis: recent insights into inhaled antibiotic treatment and future perspectives
G Taccetti, M Francalanci, G Pizzamiglio, B Messore… - Antibiotics, 2021 - mdpi.com
Although new inhaled antibiotics have profoundly improved respiratory diseases in cystic
fibrosis (CF) patients, lung infections are still the leading cause of death. Inhaled antibiotics …
fibrosis (CF) patients, lung infections are still the leading cause of death. Inhaled antibiotics …
Selective permeability of mucus barriers
Highlights•Mucus filters particles based on size and surface chemistry.•Simple descriptors
like net charge are inadequate predictors for mucus interaction.•A variety of nanoparticle …
like net charge are inadequate predictors for mucus interaction.•A variety of nanoparticle …
Targeted delivery of antibiotics to the infected pulmonary tissues using ROS-responsive nanoparticles
Y Wang, Q Yuan, W Feng, W Pu, J Ding… - Journal of …, 2019 - Springer
Background Immunocompromised individuals and those with lung dysfunction readily
acquire pulmonary bacterial infections, which may cause serious diseases and carry a …
acquire pulmonary bacterial infections, which may cause serious diseases and carry a …
Metal complexes—a promising approach to target biofilm associated infections
Microbial biofilms are represented by sessile microbial communities with modified gene
expression and phenotype, adhered to a surface and embedded in a matrix of self-produced …
expression and phenotype, adhered to a surface and embedded in a matrix of self-produced …
Targeting mucus barrier in respiratory diseases by chemically modified advanced delivery systems
Mucus gel constitutes of heavily cross-linked mucin fibers forming a viscoelastic, dense
porous network that coats all the exposed epithelia not covered with the skin. The layer …
porous network that coats all the exposed epithelia not covered with the skin. The layer …
pH-Responsive, Charge-Reversing Layer-by-Layer Nanoparticle Surfaces Enhance Biofilm Penetration and Eradication
E Deiss-Yehiely, G Cárcamo-Oyarce… - ACS biomaterials …, 2023 - ACS Publications
Microbes entrenched within biofilms can withstand 1000-fold higher concentrations of
antibiotics, in part due to the viscous extracellular matrix that sequesters and attenuates …
antibiotics, in part due to the viscous extracellular matrix that sequesters and attenuates …
Current status of in vitro models and assays for susceptibility testing for wound biofilm infections
TF Bahamondez-Canas, LA Heersema, HDC Smyth - Biomedicines, 2019 - mdpi.com
Biofilm infections have gained recognition as an important therapeutic challenge in the last
several decades due to their relationship with the chronicity of infectious diseases. Studies …
several decades due to their relationship with the chronicity of infectious diseases. Studies …
Lipid-polymer hybrid nanoparticles carrying linezolid improve treatment of methicillin-resistant Staphylococcus aureus (MRSA) harbored inside bone cells and biofilms
P Guo, BA Buttaro, HY Xue, NT Tran… - European Journal of …, 2020 - Elsevier
Methicillin-resistant Staphylococcus aureus (MRSA) is the most prevalent pathogen causing
osteomyelitis. The tendency of MRSA to evade standard antibiotic treatment by hiding inside …
osteomyelitis. The tendency of MRSA to evade standard antibiotic treatment by hiding inside …
Peptides as surface coatings of nanoparticles that penetrate human cystic fibrosis sputum and uniformly distribute in vivo following pulmonary delivery
Therapeutic delivery of drug and gene delivery systems have to traverse multiple biological
barriers to achieve efficacy. Mucosal administration, such as pulmonary delivery in cystic …
barriers to achieve efficacy. Mucosal administration, such as pulmonary delivery in cystic …