Negatively charged tissues are ubiquitous in the human body and are associated with a
number of common diseases yet remain an outstanding challenge for targeted drug delivery …

Although new inhaled antibiotics have profoundly improved respiratory diseases in cystic
fibrosis (CF) patients, lung infections are still the leading cause of death. Inhaled antibiotics …

Highlights•Mucus filters particles based on size and surface chemistry.•Simple descriptors
like net charge are inadequate predictors for mucus interaction.•A variety of nanoparticle …

Background Immunocompromised individuals and those with lung dysfunction readily
acquire pulmonary bacterial infections, which may cause serious diseases and carry a …

Microbial biofilms are represented by sessile microbial communities with modified gene
expression and phenotype, adhered to a surface and embedded in a matrix of self-produced …

Mucus gel constitutes of heavily cross-linked mucin fibers forming a viscoelastic, dense
porous network that coats all the exposed epithelia not covered with the skin. The layer …

Microbes entrenched within biofilms can withstand 1000-fold higher concentrations of
antibiotics, in part due to the viscous extracellular matrix that sequesters and attenuates …

Biofilm infections have gained recognition as an important therapeutic challenge in the last
several decades due to their relationship with the chronicity of infectious diseases. Studies …

Methicillin-resistant Staphylococcus aureus (MRSA) is the most prevalent pathogen causing
osteomyelitis. The tendency of MRSA to evade standard antibiotic treatment by hiding inside …

Therapeutic delivery of drug and gene delivery systems have to traverse multiple biological
barriers to achieve efficacy. Mucosal administration, such as pulmonary delivery in cystic …