Telomerase is a key enzyme for cell survival that prevents telomere shortening and the
subsequent cellular senescence that is observed after many rounds of cell division. In …

Sinonasal mucosal melanoma is a rare tumor arising within the nasal cavity, paranasal
sinuses, or nasopharynx (sinonasal tract). This study evaluated 90 cases diagnosed in 29 …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

Soft tissue undifferentiated round cell sarcoma (URCS) occurring in infants is a
heterogenous group of tumors, often lacking known genetic abnormalities. On the basis of at …

Cancers require telomere maintenance mechanisms for unlimited replicative potential. They
achieve this through TERT activation or alternative telomere lengthening associated with …

Synergistic effects of BRAF V600E and TERT promoter mutations on the poor clinical
outcomes in papillary thyroid cancer (PTC) have been demonstrated. The potential …

The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation
and senescence of normal somatic cells as well as cancer cells. This complex is comprised …

Aims Clear cell sarcoma of the kidney (CCSK) is a rare paediatric renal malignant tumour.
The majority of CCSK s have internal tandem duplications (ITD s) of the BCOR gene …

Pediatric brain and spinal cancers are collectively the leading disease-related cause of
death in children; thus, we urgently need curative therapeutic strategies for these tumors. To …

Background Single‐cell transcriptomics has been used to investigate various tumors to
elucidate the molecular distinction of all cell type compositions of a complex mix. Aims This …