Progestins as endocrine disrupters in aquatic ecosystems: concentrations, effects and risk assessment

K Fent - Environment international, 2015 - Elsevier
In aquatic ecosystems, progesterone (P4) and synthetic progestins (gestagens) originate
from excretion by humans and livestock. Synthetic progestins are used for contraception and …

The challenge presented by progestins in ecotoxicological research: a critical review

V Kumar, AC Johnson, A Trubiroha… - … science & technology, 2015 - ACS Publications
Around 20 progestins (also called gestagens, progestogens, or progestagens) are used
today in assisting a range of medical conditions from endometrial cancer to uterine bleeding …

Long-term exposure to environmentally relevant concentrations of progesterone and norgestrel affects sex differentiation in zebrafish (Danio rerio)

YQ Liang, GY Huang, SS Liu, JL Zhao, YY Yang… - Aquatic Toxicology, 2015 - Elsevier
The aim of this study was to investigate the effects of progestins on the sex differentiation of
zebrafish by measuring the sex ratio and transcriptions of genes related to sex differentiation …

[HTML][HTML] From single chemicals to mixtures—Reproductive effects of levonorgestrel and ethinylestradiol on the fathead minnow

TJ Runnalls, N Beresford, S Kugathas… - Aquatic Toxicology, 2015 - Elsevier
The aquatic environment is polluted with thousands of chemicals. It is currently unclear
which of these pose a significant threat to aquatic biota. The typical exposure scenario is …

The progestin norethindrone alters growth, reproductive histology and gene expression in zebrafish (Danio rerio)

YQ Liang, Z Jing, CG Pan, Z Lin, Z Zhen, L Hou… - Chemosphere, 2020 - Elsevier
The aim of this study was to assess the long-term effects of synthetic progestin
norethindrone (NET) on the growth, reproductive histology, and transcriptional expression …

The progestin levonorgestrel affects sex differentiation in zebrafish at environmentally relevant concentrations

J Hua, J Han, Y Guo, B Zhou - Aquatic Toxicology, 2015 - Elsevier
Synthetic progestins have become widespread environmental contaminants and may cause
adverse effects on fish. In the present study, we investigated the effects of levonorgestrel …

Regulation of zebrafish (Danio rerio) locomotor behavior and circadian rhythm network by environmental steroid hormones

Y Zhao, K Zhang, K Fent - Environmental Pollution, 2018 - Elsevier
Environmental exposure of fish to steroid hormones through wastewater and agricultural
runoff may pose a health risk. Thus far, ecotoxicological studies have largely been focused …

The interactive effects of ethinylestradiol and progesterone on transcriptional expression of genes along the hypothalamus–pituitary–thyroid axis in embryonic …

J Tan, H Chen, S Chen, J Hu, X Wang, Y Wang… - Science of The Total …, 2022 - Elsevier
Progestins and estrogens are widespread in various aquatic environments and their
potential endocrine disruption effects to aquatic organisms have drawn growing concern …

Effects of antiandrogenic progestins, chlormadinone and cyproterone acetate, and the estrogen 17α-ethinylestradiol (EE2), and their mixtures: transactivation with …

PF Siegenthaler, P Bain, F Riva, K Fent - Aquatic Toxicology, 2017 - Elsevier
Synthetic progestins act as endocrine disrupters in fish but their risk to the environment is not
sufficiently known. Here, we focused on an unexplored antiandrogenic progestin …

Benzophenones and synthetic progestin in wastewater and sediment from farms, WWTPs and receiving surface water: distribution, sources, and ecological risks

S Wang, Z Huo, J Gu, G Xu - RSC advances, 2021 - pubs.rsc.org
Farms and wastewater treatment plants (WWTPs) are important sources of endocrine
disruptors, which may have potential adverse effects on the nearby receiving river and …