The emerging field of oncolytic virus-based cancer immunotherapy
Oncolytic viruses (OVs) provide novel and promising therapeutic options for patients with
cancers resistant to traditional therapies. Natural or genetically modified OVs are …
cancers resistant to traditional therapies. Natural or genetically modified OVs are …
Shattering barriers toward clinically meaningful MSC therapies
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
Oncolytic viruses: a new class of immunotherapy drugs
HL Kaufman, FJ Kohlhapp, A Zloza - Nature reviews Drug discovery, 2015 - nature.com
Oncolytic viruses represent a new class of therapeutic agents that promote anti-tumour
responses through a dual mechanism of action that is dependent on selective tumour cell …
responses through a dual mechanism of action that is dependent on selective tumour cell …
Oncolytic virotherapy
SJ Russell, KW Peng, JC Bell - Nature biotechnology, 2012 - nature.com
Oncolytic virotherapy is an emerging treatment modality that uses replication-competent
viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a …
viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a …
Talimogene laherparepvec (T-VEC) and other oncolytic viruses for the treatment of melanoma
PK Bommareddy, A Patel, S Hossain… - American journal of …, 2017 - Springer
Many mammalian viruses have properties that can be commandeered for the treatment of
cancer. These characteristics include preferential infection and replication in tumor cells, the …
cancer. These characteristics include preferential infection and replication in tumor cells, the …
Emerging nano-/biotechnology drives oncolytic virus-activated and combined cancer immunotherapy
C Fang, G Xiao, T Wang, L Song, B Peng, B Xu… - Research, 2023 - spj.science.org
Oncolytic viruses (OVs) as one promising antitumor methods have made important
contributions to tumor immunotherapy, which arouse increasing attention. They provide the …
contributions to tumor immunotherapy, which arouse increasing attention. They provide the …
Molecular imaging
R Weissleder, U Mahmood - Radiology, 2001 - pubs.rsna.org
The term molecular imaging can be broadly defined as the in vivo characterization and
measurement of biologic processes at the cellular and molecular level. In contradistinction to …
measurement of biologic processes at the cellular and molecular level. In contradistinction to …
Oncolytic viruses as therapeutic cancer vaccines
DL Bartlett, Z Liu, M Sathaiah, R Ravindranathan… - Molecular cancer, 2013 - Springer
Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. They kill
infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells …
infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells …
Antitumor benefits of antiviral immunity: an underappreciated aspect of oncolytic virotherapies
Oncolytic viruses (OVs) represent a new class of cancer immunotherapeutics. Administration
of OVs to cancer-bearing hosts induces two distinct immunities: antiviral and antitumor …
of OVs to cancer-bearing hosts induces two distinct immunities: antiviral and antitumor …
A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults …
NG Rainov - Human gene therapy, 2000 - liebertpub.com
Previous uncontrolled clinical trials have shown the in vivo retrovirus (RV)-mediated
transduction of glioblastoma cells with the herpes simplex virus thymidine kinase (HSV-tk) …
transduction of glioblastoma cells with the herpes simplex virus thymidine kinase (HSV-tk) …