Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

Understanding transmission biology at an individual level is a key component of intervention
strategies that target the spread of malaria parasites from human to mosquito. Gametocytes …

Understanding the importance of gametocyte density on human-to-mosquito transmission is
of immediate relevance to malaria control. Previous work (Churcher et al., 2013) indicated a …

Background The discovery of malaria transmission-blocking compounds is seen as key to
malaria elimination strategies and gametocyte-screening platforms are critical filters to …

Renewed interest in malaria eradication has placed greater emphasis on the development
of tools to interrupt Plasmodium transmission, such as transmission-blocking vaccines …

A mosquito needs to ingest at least one male and one female gametocyte to become
infected with malaria. The sex of Plasmodium falciparum gametocytes can be determined …

Translation regulation plays an important role during gametocytogenesis in the malaria
parasite, a process that is obligatory for the transmission of the parasite through mosquito …

Background Single low-dose primaquine (PQ) reduces Plasmodium falciparum infectivity
before it impacts gametocyte density. Here, we examined the effect of PQ on gametocyte sex …

Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in
falciparum malaria include measurement of the duration of gametocytaemia, the rate of …

Plasmodium parasites have a complex life cycle that includes development in the human
host as well as the Anopheles vector. Successful transmission of the parasite between its …