Blood transfusions have been the cornerstone of life support since the introduction of the
ABO classification in the 20th century. The physiologic goal is to restore adequate tissue …

The transfusion approach to massive hemorrhage has continually evolved since it began in
the early 1900s. It started with fresh whole blood and currently consists of virtually exclusive …

Objective To relate in-hospital mortality to early transfusion of plasma and/or platelets and to
time-varying plasma: red blood cell (RBC) and platelet: RBC ratios. Design Prospective …

Background: Patients with severe traumatic injuries often present with coagulopathy and
require massive transfusion. The risk of death from hemorrhagic shock increases in this …

Introduction Evidence-based recommendations are needed to guide the acute management
of the bleeding trauma patient, which when implemented may improve patient outcomes …

Objective: To determine the effect of blood component ratios in massive transfusion (MT), we
hypothesized that increased use of plasma and platelet to red blood cell (RBC) ratios would …

Background: Massive transfusion (MT) occurs in about 3% of civilian and 8% of military
trauma patients. Although many centers have implemented MT protocols, most do not have …

Introduction Prediction of massive transfusion (MT) among trauma patients is difficult in the
early phase of trauma management. Whole-blood thromboelastometry (ROTEM®) tests …

Introduction Evidence-based recommendations can be made with respect to many aspects
of the acute management of the bleeding trauma patient, which when implemented may …

Background: In the prehospital environment, the failure of medical providers to recognize
latent physiologic derangement in patients with compensated shock may risk undertriage …