In the context of the coronavirus disease 2019 (COVID-19) pandemic, the global healthcare
community has raced to find effective therapeutic agents against severe acute respiratory …

Depression is an emotional disorder that is problematic in psychiatry owing to its unclear
etiology and unknown pathogenesis. Traditional Chinese medicine formulations such as …

Multiple sclerosis (MS) is an incurable autoimmune disease and is currently treated by
systemic immunosuppressants with off-target side effects. Although aberrant myeloid …

Seizure disorders are common, affecting both the young and the old. Currently available
antiseizure drugs are ineffective in a third of patients and have been developed with a focus …

Status epilepticus (SE) is a life-threatening neurological emergency often refractory to
available treatment options. It is a very heterogeneous condition in terms of clinical …

Status epilepticus (SE) is a very heterogeneous clinical condition often refractory to
available treatment options. Evidence in animal models shows that neuroinflammation …

Background Temporal lobe epilepsy (TLE) is the most common form of partial epilepsy and
is accompanied, in one third of cases, by resistance to antiepileptic drugs (AED). Most AED …

Huntingtin (HTT)-lowering therapies show great promise in treating Huntington's disease.
We have developed a microRNA targeting human HTT that is delivered in an adeno …

Acute intoxication with organophosphates (OPs) can cause a potentially fatal cholinergic
crisis characterized by peripheral parasympathomimetic symptoms and seizures that rapidly …

Increased permeability of the blood–brain barrier (BBB) following cerebral injury results in
regional extravasation of plasma proteins and can critically contribute to the pathogenesis of …