Comorbidities in mild autonomous cortisol secretion and the effect of treatment: systematic review and meta-analysis

ICM Pelsma, M Fassnacht, S Tsagarakis… - European Journal of …, 2023 - academic.oup.com
Objective To assess (1) comorbidities associated with and (2) treatment strategies for
patients with adrenal incidentalomas and mild autonomous cortisol secretion (MACS;> 1.8 …

European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the …

M Fassnacht, S Tsagarakis, M Terzolo… - European Journal of …, 2023 - academic.oup.com
Adrenal incidentalomas are adrenal masses detected on imaging performed for reasons
other than suspected adrenal disease. In most cases, adrenal incidentalomas are …

Glucose and lipid metabolism abnormalities in C ushing's syndrome

R Salehidoost, M Korbonits - Journal of Neuroendocrinology, 2022 - Wiley Online Library
Prolonged excess of glucocorticoids (GCs) has adverse systemic effects leading to
significant morbidities and an increase in mortality. Metabolic alterations associated with the …

High prevalence of frailty in patients with adrenal adenomas and adrenocortical hormone excess: a cross-sectional multi-centre study with prospective enrolment

P Dogra, L Šambula, J Saini… - European journal of …, 2023 - academic.oup.com
Objective Frailty, characterized by multi-system decline, increases vulnerability to adverse
health outcomes and can be measured using Frailty Index (FI). We aimed to assess the …

Pathophysiology of mild hypercortisolism: from the bench to the bedside

V Favero, A Cremaschi, C Parazzoli, A Falchetti… - International Journal of …, 2022 - mdpi.com
Mild hypercortisolism is defined as biochemical evidence of abnormal cortisol secretion
without the classical detectable manifestations of overt Cushing's syndrome and, above all …

Cardiovascular risk markers in adults with adrenal incidentaloma and mild autonomous cortisol secretion

AX Chen, A Radhakutty, SM Drake, A Kiu… - The Journal of …, 2024 - academic.oup.com
Context Many adrenal adenomas exhibit mild autonomous cortisol secretion (MACS).
Although MACS is associated with increased cardiovascular mortality, the underlying …

Risk of dementia and psychiatric or sleep disorders after diagnosis of adrenal adenomas: a population-based cohort study

D Li, S Singh, CD Zhang, RJ Kaur… - European journal of …, 2023 - academic.oup.com
Objective Adrenal adenomas are commonly encountered in clinical practice. To date,
population-based data on their impact on cognition, mental health, and sleep are lacking …

Unique Gene Expression Signature in Periadrenal Adipose Tissue Identifies a High Blood Pressure Group in Patients With Cushing Syndrome

U Stifel, F Vogel, G Caratti, M Reincke… - Hypertension, 2023 - Am Heart Assoc
BACKGROUND: Cushing syndrome (CS) is a rare disease caused by excess cortisol levels
with high cardiovascular morbidity and mortality. Hypertension in CS promotes …

Effect of mild cortisol cosecretion on body composition and metabolic parameters in patients with primary hyperaldosteronism

N Mansour, D Bruedgam, U Dischinger… - Clinical …, 2024 - Wiley Online Library
Objective To investigate the effects of simultaneous cortisol cosecretion (CCS) on body
composition in computed tomography (CT)‐imaging and metabolic parameters in patients …

Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches

A Prete, I Bancos - Nature Reviews Endocrinology, 2024 - nature.com
The majority of incidentally discovered adrenal tumours are benign adrenocortical
adenomas and the prevalence of adrenocortical adenomas is around 1–7% on cross …